Congratulations to Joern Karhausen, MD, Assistant Professor in the Cardiac Division of Anesthesiology, who has been awarded a one-year, $414,362 NIH High Priority, Short-Term Project Award (R56) from the National Heart, Lung, and Blood Institute entitled, “Platelet/Mast Cell Interactions as Determinants of End-Organ Injury in Cardiac Surgery.”
Dr. Karhausen and his collaborators propose to clarify causal effects between mast cell activation and platelet aggregation during deep hypothermic circulatory arrest (DHCA) and define the implications of platelet/mast cell interactions for end-organ injury. In addition, they aim to define the impact of perioperative mast cell activation on end-organ injury in patients undergoing DHCA. In doing so, they will address crucial feedback from the scientific review of their recent R01 application in order to successfully reapply for federal funding. A team of experts in the fields of mast cell (Dr. Soman Abraham, Dept. of Pathology), platelets (Dr. Wolfgang Bergmeier, UNC), animal models of cardiopulmonary bypass (Dr. Ma Qing, Anesthesiology) and clinical statistics and epidemiology (Dr. Miklos Kertai, Anesthesiology) provide strong support for successful completion.