Drs. Thomas Buchheit and Thomas Van de Ven with Duke Anesthesiology’s newly established Center for Translational Pain Medicine, along with their colleagues at the department’s Nerve Injury Pain Laboratory, publish manuscripts that could have a significant impact on patients suffering from chronic pain, post-amputation.
The article featured in the journal Pain on September 23, 2016, titled “Differential Expression of Systemic Inflammatory Mediators in Amputees With Chronic Residual Limb Pain,” has implications for biologic targets and future non-opioid therapies. Dr. Van de Ven and Alex Chamessian (of the Duke University School of Medicine) are co-first authors of this paper.
Chronic post-surgical pain impacts the majority of amputees, with more than half experiencing neuralgic residual limb pain. As part of the Veterans Integrated Pain Evaluation Research (VIPER) study, investigators examined links between systemic inflammatory mediator levels and chronic residual limb pain. Study results suggest that chronic post-amputation residual limb pain is associated with excessive inflammatory response to injury or to inadequate resolution of the post-injury inflammatory state. The impact of pain catastrophizing on residual limb pain may be due in part to common underlying inflammatory mechanisms. Dr. Buchheit, chief of Duke Anesthesiology’s Pain Medicine Division and Dr. Hung-Lun (John) Hsia, co-authored this paper.
The article featured in the journal Pain Medicine on July 8, 2016, titled “Perioperative Pain Management Strategies for Amputation: A Topical Review,” highlights why patient-tailored analgesic regimens utilizing catheter-based techniques are essential in the acute post-amputation phase. Co-authors of this paper include Drs. Buchheit, Van de Ven and Hsia.