Publications

  1. Podgoreanu MV, Schwinn DA. New paradigms in cardiovascular medicine – Emerging technologies and practices: Perioperative genomics. J Am Coll Cardiol, Dec, 2005; 1965-77
  2. Stafford-Smith M, Podgoreanu M, Swaminathan M, Phillips-Bute B, Mathew JP, Hauser EH, Winn MP, Milano C, Nielsen DM, Smith M, Morris R, Newman MF, Schwinn DA for the PEGASUS Investigators. Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery. Am J Kidney Dis 2005; 45: 519-530
  3. Welsby IJ, Podgoreanu MV, Phillips-Bute B, White WD, Nielsen DM, Mathew JP, Smith PK, Newman MF, Schwinn DA, Stafford-Smith M, for the PEGASUS Investigators. Genetic basis for bleeding after cardiac surgery – A preliminary report. J Thromb Haemost 2005; 3: 1206-1213
  4. Grocott HP, White WD, Morris RW, Podgoreanu MV, Mathew JP, Schwinn DA, Newman MF, for the PEGASUS Investigators. Genetic polymorphisms and the risk of stroke after cardiac surgery. Stroke 2005 Sep;369:1854-8
  5. Podgoreanu MV, Michelotti GA, Sato Y, Smith MP, Lin S, Grocott HP, Booth JV, Schwinn DA. Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of pro-inflammatory genes. J Thorac Cardiovasc Surg 2005; 130 : 330-339
  6. Moretti EW, Morris RW, Schwinn DA, Podgoreanu MV, Newman MF, Bennett E, Moulin VG, Mba UU, Laskowitz DT, for the PEGASUS Investigators. APOE polymorphism is associated with sepsis risk in surgical patients. Crit Care Med; 2005; 33(11); 2521-2526
  7. Podgoreanu MV, Mathew JP. Prophylaxis against postoperative atrial fibrillation: current progress and future directions. JAMA 2005; 294(24): 3093-100
  8. Podgoreanu MV, White WD, Morris RW, Mathew JP, Stafford-Smith M, Welsby IJ, Grocott HP, Milano CA, Newman MF, Schwinn DA; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction following cardiac surgery. Circulation 2006; 114(Suppl 1):275-281
  9. Newman MF, Mathew JP, Grocott HP, Mackensen GB, Monk T, Welsh-Bohmer KA, Blumenthal JA, Laskowitz DT, Mark DB. Central nervous system injury associated with cardiac surgery. Lancet 2006; 368:694-703
  10. Moretti EW, Newman MF, Muhlbaier LH, Whellan D, Petersen RP, Rossignol D, McCants CB Jr, Phillips-Bute B, Bennett-Guerrero E. Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery. Arch Surg 2006;141(7):637-41
  11. Swaminathan M, Stafford-Smith M. Renal dysfunction after vascular surgery. Curr Opin Anaesthesiol 2003;16(1):45-51
  12. Grocott HP. Genetics and outcome after cardiac surgery. J Extra Corpor Technol 2006;38(1):49-51
  13. Yoshitani K, de Lange F, Ma Q, Grocott HP, Mackensen GB. Reduction in air bubble size using perfluorocarbons during cardiopulmonary bypass in the rat. Anesth Analg 2006;103(5):1089-93
  14. Jungwirth B, Mackensen GB, Blobner M, Neff F, Reichart B, Kochs EF, Nollert G. Neurologic outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats: description of a new model. J Thorac Cardiovasc Surg 2006;131(4):805-12
  15. Grocott HP, Mackensen GB. Apolipoprotein E genotype and S100beta after cardiac surgery: is inflammation the link? Anesth Analg 2005;100(6):1869-70
  16. Jungwirth B, Gordan ML, Blobner M, Schmehl W, Kochs EF, Mackensen GB. Xenon impairs neurocognitive and histologic outcome after cardiopulmonary bypass combined with cerebral air embolism in rats. Anesthesiology 2006;104(4):770-6
  17. Dieleman JM, de Lange F, Houston RJ, Biessels GJ, Bar PR, Mackensen GB, Grocott HP, Kalkman CJ. Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat. Life Sci 2006; 79(6):551-8
  18. Schambra UB, Mackensen GB, Stafford-Smith M, Haines DE, Schwinn DA. Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. Neuroscience 2005;135(2):507-23
  19. Mathew JP, Rinder HM, Smith BR, Newman MF, Rinder CS. Transcerebral platelet activation after aortic cross-clamp release is linked to neurocognitive decline. Ann Thorac Surg 2006;81(5):1644-9
  20. Zhang Q, Morris RW, Mathew JP, Schwinn DA, Newman MK, Podgoreanu MV. Clinical, procedural and genetic determinants of QTc prolongation following cardiac surgery. 2006. Abstract to the Society of Cardiovascular Anesthesiologist’s national meeting.
  21. Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery. Mathew JP, Podgoreanu MV, Grocott HP, White WD, Morris RW, Stafford-Smith M, Mackensen GB, Rinder CS, Blumenthal JA, Schwinn DA, Newman MF; PEGASUS Investigative Team. J Am Coll Cardiol. 2007 May 15;49(19):1934-42.
  22. Pharmacogenomics and end-organ susceptibility to injury in the perioperative period.Schwinn DA, Podgoreanu M. Best Pract Res Clin Anaesthesiol. 2008 Mar;22(1):23-37.
  23. A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper.de Lange F, Yoshitani K, Podgoreanu MV, Grocott HP, Mackensen GB.J Cardiothorac Surg. 2008 Aug 19;3:51.
  24. Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery.Phillips-Bute B, Mathew JP, Blumenthal JA, Morris RW, Podgoreanu MV, Smith M, Stafford-Smith M, Grocott HP, Schwinn DA, Newman MF; Perioperative Genetics and Safety Outcomes Investigative Team. Psychosom Med. 2008 Nov;70(9):953-9.
  25. Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion.Turer AT, Stevens RD, Bain JR, Muehlbauer MJ, van der Westhuizen J, Mathew JP, Schwinn DA, Glower DD, Newgard CB, Podgoreanu MV.Circulation. 2009 Apr 7;119(13):1736-46.
  26. Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery.Welsby IJ, Podgoreanu MV, Phillips-Bute B, Morris R, Mathew JP, Smith PK, Newman MF, Schwinn DA, Stafford-Smith M; Perioperative Genetics and Safety Outcomes Study Investigative Team. J Cardiothorac Vasc Anesth. 2010 Jun;24(3):427-33.
  27. Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. McDonagh DL, Mathew JP, White WD, Phillips-Bute B, Laskowitz DT, Podgoreanu MV, Newman MF; Neurologic Outcome Research Group. Anesthesiology. 2010 Apr;112(4):852-9.
  28. Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. Heinzen EL, Radtke RA, Urban TJ, Cavalleri GL, Depondt C, Need AC, Walley NM, Nicoletti P, Ge D, Catarino CB, Duncan JS, Kasperaviciūte D, Tate SK, Caboclo LO, Sander JW, Clayton L, Linney KN, Shianna KV, Gumbs CE, Smith J, Cronin KD, Maia JM, Doherty CP, Pandolfo M, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Kälviäinen R, Eriksson K, Kantanen AM, Dorn T, Hansen J, Krämer G, Steinhoff BJ, Wieser HG, Zumsteg D, Ortega M, Wood NW, Huxley-Jones J, Mikati M, Gallentine WB, Husain AM, Buckley PG, Stallings RL, Podgoreanu MV, Delanty N, Sisodiya SM, Goldstein DB. Am J Hum Genet. 2010 May 14;86(5):707-18.
  29. Energetics and metabolism in the failing heart: important but poorly understood.Turer AT, Malloy CR, Newgard CB, Podgoreanu MV. Curr Opin Clin Nutr Metab Care. 2010 Jul;13(4):458-65.
  30. Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses. Lobato RL, White WD, Mathew JP, Newman MF, Smith PK, McCants CB, Alexander JH, Podgoreanu MV; Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. Circulation. 2011 Sep 13;124(11 Suppl):S143-8.
  31. Pharmacogenomics of beta-blockers and statins: possible implications for perioperative cardiac complications. Kertai MD, Fontes M, Podgoreanu MV. J Cardiothorac Vasc Anesth. 2012 Dec;26(6):1101-14.

Contact Us

Perioperative Genomics Program
Department of Anesthesiology
Duke University Medical Center
5691 HAFS Building, 5th Floor
DUMC 3094
Durham, NC 27710

Administrative Coordinator: Jaime Cooke
Phone: 919-681-6532
Fax: 919-681-8994
jaime.cooke@duke.edu