The focus of our laboratory is to understand the role of G protein-coupled receptors in human diseases. Our current focus is to examine the role of the Neurokinin-1/substance P receptor and its interactions with receptor tyrosine kinases in glioblastoma multiforme (GBM). The goal of these translational studies is to develop an effective therapy to halt the growth of GBM. An ongoing side project, which is being conducted in collaboration with several clinicians, is to understand the molecular basis of postoperative delirium.
- Goldsmith LE, Kwatra MM. NK1 (Substance P) Receptor. UCSD-Nature Molecule Pages Published online: 19 Jan 2012.
- Flink BJ, Rivelli SK, Cox EA, White WD, Falcone G, Vail TP, Young CC, Bolognesi MP, Krystal AD, Trzepacz PT, Moon RE, Kwatra MM. Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly. Anesthesiology. 2012 Apr;116(4):788-96.