ACES Scholars

Current CA-1s

Rachael Mintz-Cole, MD, PhDrachael.mintz.cole@duke.edu
My graduate research focused on the immune mechanisms of mold induced asthma. I focused on the beta-glucan receptor, Dectin-1, and downstream responses.  All molds contain beta-glucans in their cell wall. However, not all molds have beta-glucans on their surface, available to bind to Dectin-1. This results in different downstream immune responses. Importantly, this plays a role in the ability of different molds to induce asthma. I also spent some time elucidating the role of proto-oncogene DEK in epithelial cancer.   I am currently interested in the immune mechanisms underlying critical illness.

Selected Publications:

  1. Kuethe JW, Mintz-Cole R, Johnson BL 3rd, Midura EF, Caldwell CC, Schneider BS. “Assessing the immune status of critically ill trauma patients by flow cytometry.” Nurs Res. 2014 Nov-Dec;63(6):426-34. doi: 10.1097/NNR.0000000000000061. Review. PMID: 25350542
  2. Mintz-Cole RA, Brandt EB, Bass SA, Gibson AM, Reponen T, Khurana Hershey GK. “Surface availability of beta-glucans is critical determinant of host immune response to Cladosporium cladosporioides.” J Allergy Clin Immunol. 2013 Jul;132(1):159-69. doi: 10.1016/j.jaci.2013.01.003. Epub 2013 Feb 10. PMID: 23403046
  3. Mintz-Cole RA, Gibson AM, Bass SA, Budelsky AL, Reponen T, Hershey GK. “Dectin-1 and IL-17A suppress murine asthma induced by Aspergillus versicolor but not Cladosporium cladosporioides due to differences in β-glucan surface exposure.” J Immunol. 2012 Oct 1;189(7):3609-17. Epub 2012 Sep 7. PMID: 22962686
  4. Wise-Draper TM, Mintz-Cole RA, Morris TA, Simpson DS, Wikenheiser-Brokamp KA, Currier MA, Cripe TP, Grosveld GC, Wells SI. “Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.” Cancer Res. 2009 Mar 1;69(5):1792-9. doi: 10.1158/0008-5472.CAN-08-2304. Epub 2009 Feb 17. PMID: 19223548
  5. Wise-Draper TM, Morreale RJ, Morris TA, Mintz-Cole RA, Hoskins EE, Balsitis SJ, Husseinzadeh N, Witte DP, Wikenheiser-Brokamp KA, Lambert PF, Wells SI. “DEK proto-oncogene expression interferes with the normal epithelial differentiation program.” Am J Pathol. 2009 Jan;174(1):71-81. doi: 10.2353/ajpath.2009.080330. Epub 2008 Nov 26. PMID: 19036808

Current CA-2s

J. Taylor Herbert, MD, PhDjames.herbert@duke.edu
I majored in neuroscience at Davidson College, then did a year-long research fellowship at the NIH/NINDS studying the effects of neurotrophic factors and chemokines on neuronal apoptosis in the postnatal cerebellum. Prior to matriculation at Duke, I did research at the University of Virginia on the roles of potassium ion leak channels on neuronal control of brainstem respiratory neurons. My graduate research at Duke University explored the roles of PI3K and mTOR inhibition on protein translation initiation and autophagic cell death in prostate cancer. I am currently a second year anesthesiology resident at Duke, and am working on identifying a mentor and starting my ACES program research project.

Publications:

  1. Balakumaran BS, Herbert JT, Febbo PG. MYC activity mitigates response to rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy. Autophagy. 2010 Feb;6(2):281-2. Epub 2010 Feb 10. PubMed PMID: 20026909.
  2. Kaiser C, Dobrikova EY, Bradrick SS, Shveygert M, Herbert JT, Gromeier M. Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo. RNA. 2008 Oct;14(10):2170-82. doi: 10.1261/rna.1171808. Epub 2008 Aug 28. PubMed PMID: 18755839; PubMed Central PMCID: PMC2553731.
  3. Yabe T, Herbert JT, Takanohashi A, Schwartz JP. Treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor in vitro enhances expression of other neurotrophic factors as well as cytokines and chemokines. J Neurosci Res. 2004 Sep 1;77(5):642-52. PubMed PMID:15352210.
  4. Selley DE, Herbert JT, Morgan D, Cook CD, Picker MJ, Sim-Selley LJ. Effect of strain and sex on mu opioid receptor-mediated G-protein activation in rat brain. Brain Res Bull. 2003 May 15;60(3):201-8. PubMed PMID: 12754081.
  5. Herbert JT. Research jobs for recent college graduates: A comparison between traditional lab technician positions and NIH’s postbaccalaureate IRTA fellowship. J Undergrad Neurosci Educ. 2003 Jun 15;1(2):E4-9. Print 2003 Spring. PubMed PMID: 23741203; PubMed Central PMCID: PMC3670789.

S. Kendall Smith, MD, PhD | sarah.k.smith@duke.edu
My doctoral research involved elucidating molecular mechanisms by which homologous chromosomes faithfully segregate during female meiosis using the model organism, Drosophila melanogaster.  Going forward, I aim to combine my passion for genetics and molecular physiology with anesthesiology and critical care medicine.

Selected Abstracts & Publications:

  1. Bonner AM, Hughes SE, Chisholm JA, Smith SK, Slaughter BD, Unruh JR, Collins KA, Friederichs JM, Florens L, Swanson SK, Pelot MC, Miller DE, Washburn MP, Jaspersen SL, Hawley RS.  Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):E1222-31. doi: 10.1073/pnas.1301690110. Epub 2013 Mar 11.
  2. Smith SK,  Jaspersen SL,  Hawley RS. “Matrimony ties Polo down: can this kinase get free?” Cell Cycle. 2008 Mar 15; 7(6): 698-701.
  3. Tash JS,  Chakrasali R,  Jakkaraj SR,  Hughes J, Smith SK,  Hornbaker K,  Heckert LL,  Ozturk SB,  Hadden MK,  Kinzy TG,  Blagg BS,  Georg GI. “Gamendazole, an Orally Active Indazole Carboxylic Acid Male Contraceptive Agent, Targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and Stimulates Il1a Transcription in Rat Sertoli Cells.” Biol Reprod. 2008 Jun; 78(6): 1139-52.

Current CA-3s

Jamie Privratsky, MD, PhD | jamie.privratsky@duke.edu
My graduate research focused on the role of the cell adhesion molecule platelet endothelial cell adhesion molecule (PECAM)-1 in vascular inflammation, specifically in in vivo and in vitro models of sepsis and vascular integrity.  Moving forward, I will be using my background in inflammation in the laboratory of Dr. Steven Crowley to help elucidate mechanisms of inflammatory and immune cell derangement in models of acute kidney injury (AKI) and their progression to chronic kidney disease.  The goal of my research is to use transgenic and cell-type specific genetic knock out technology to examine TNFα- and IL-1-mediated injury in cisplatin-and hemorrhagic shock-induced AKI.  In addition, as a translational project, our department will be collaborating with the Department of Cardiology at Duke in trying to identify genetic susceptibility to post-cardiac bypass AKI.

Selected references:

  1. Privratsky JR, Tourdot BT, Newman DK, Newman PJ.  The anti-inflammatory actions of PECAM-1 do not involve regulation of endothelial cell NFκB.  J Immunol.  184(6):3157-3163, 2010.
  2. Privratsky JR, Newman DK, Newman PJ. PECAM-1: Conflicts of Interest in Inflammation.  Life Sci. 87(3-4):69-82, 2010.
  3. Privratsky JR, Paddock CM, Florey O, Newman DK, Muller WA, Newman PJ. Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity. J Cell Sci. 124:1477-1485, 2011.
  4. Privratsky JR, Tilkens SB, Newman DK, Newman PJ. PECAM-1 dampens cytokine levels by preventing the excessive accumulation of cytokine-producing leukocytes during LPS-induced endotoxic Life Sci. 90:177-184, 2011.
  5. Privratsky JR and Newman PJ. PECAM-1: regulator of endothelial junctional integrity. Cell Tissue Res. 355(3):607-619, 2014.
  6. Zhang J, Patel MB, Wei QQ, Karlovich NS, Wu M, Sparks, MA, Privratsky JR, Herrera M, Crowley SD. Competing Actions of Type 1 Angiotensin Receptors in T Lymphocytes and Kidney Epithelium During Cisplatin-Induced Acute Kidney Injury: Central Role of TNFα.  J Am Soc Nephrol. In review, 2015.

Nathan Waldron, MD | nathan.waldron@duke.edu
As a medical student, my research focused on goal-directed therapy during major surgery as well as optimizing perioperative outcomes. Early in residency, I developed a keen interest in postoperative atrial fibrillation (POAF) after cardiac surgery. My current interests are 1) risk stratification and reduction of POAF, 2) autonomic mechanisms contributing to postoperative atrial fibrillation, and 3) novel preventative strategies for POAF. Additionally, I am extremely fortunate to have been awarded a Foundation for Anesthesia Education and Research (FAER) Research Fellowship Grant for a prospective clinical trial my mentor and I have designed.

Selected Publications:

  1. Kertai MD, Li YJ, Ji Y, Qi W, Lombard FW, Shah SH, Kraus WE, Stafford-Smith M, Newman MF, Milano CA, Waldron N, Podgoreanu MV, Mathew JP. Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery. Am Heart J. 2015. Accepted, publication pending.
  2. Klinger RY; Thunberg CA; White WD; Fontes M; Waldron NH; Piccini JP; Hughes GC; Podgoreanu MV; Stafford-Smith M; Newman MF; Mathew JP. “Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery.” Anesth Analg. 2015 Jul 31.
  3. Mishriky BM; Waldron NH; Habib AS. “Impact of Pregabalin on Acute and Persistent Postoperative Pain: a Systematic Review and Meta-Analysis.” Br J Anaesth. 2015 Jan;114(1):10-31.
  4. Waldron NH, Miller TE, Gan TJ. “Perioperative Goal Directed Therapy.” J Cardiothorac Vasc Anesth. 2014 Dec;28(6):1635-1641.
  5. Waldron NH; Miller TE; Thacker JK; Manchester AK; White WD; Nardiello J; Elgasim MA; Moon RE; Gan TJ. “A Prospective Comparison of Non-Invasive Cardiac Output Monitor vs. Esophageal Doppler Monitor for Goal-Directed Fluid Therapy in Colorectal Surgery Patients.” Anesth Analg. 2014 May;118(5):966-75.
  6. Waldron NH; Jones CA; Gan TJ; Allen TK; Habib AS. “Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis.” Br J Anaesth. 2013 Feb;110(2):191-200.

Recent Graduates

Miles Berger, MD, PhD
I obtained my PhD in neuro-endocrinology.  My thesis helped elucidate the role of central serotonin receptors on behavior modulation, and the role of peripheral serotonin receptors and other GPCRs in pancreatic islet cell development. My current interests are primarily in neuropharmacology and neuroscience. In particular, I am interested in the effects of anesthetic agents on neural markers of alzheimers disease, and in the possibility of using high throughput screening methods to discover the molecular targets of inhaled anesthetics and other anesthetic drugs.

Anne Cherry, MD
As a medical student, I completed a study with Dr. Richard Moon that investigated contributors to alterations in the P(ET-a)CO2 gradient during exercise underwater at the surface and at depth.  I am currently working with Dr. Claude Piantadosi on a project to investigate the pathway and regulation of the mitochondrial antioxidant response in response to sepsis (intraperitoneal, Staph Aureus).

Selected Abstracts & Publications:

  1. Cherry AD, Forkner IF, Frederick HJ, Natoli MJ, Schinazi EA, Longphre JP, Conard JL, White WD, Freiberger JJ, Stolp BW, Pollock NW, Doar PO, Boso AE, Alford EL, Walker AJ, Ma AC, Rhodes MA, Moon RE. “Predictors of increased PaCO2 during immersed prone exercise at 4.7 ATA.” J Appl Physiol. 2009 Jan;106(1):316-25.
  2. Moon RE, Cherry AD, Stolp BW, Camporesi EM. “Pulmonary gas exchange in diving.” J Appl Physiol. 2009 Feb;106(2):668-77.
  3. Wester TE, Cherry AD, Pollock NW, Freiberger JJ, Natoli MJ, Schinazi EA, Doar PO, Boso AE, Alford EL, Walker AJ, Uguccioni DM, Kernagis D, Moon RE. “Effects of head and body cooling on hemodynamics during immersed prone exercise at 1 ATA.” J Appl Physiol. 2009 Feb;106(2):691-700.
  4. Rhodes MA, Carraway MS, Piantadosi CA, Reynolds CM, Cherry AD, Wester TE, Natoli MJ, Massey EW, Moon RE, Suliman HB. “Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans.” Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H392-9.
  5. “Effect of Increased Respiratory Resistance on PaCO2 and Hemodynamics in the Submerged Exercising Diver” – Original Research Poster and Presentation
    Undersea and Hyperbaric Medical Society Annual Scientific Meeting, Kapalua Maui, HI 2007
  6. “Relative Impact of Conditional and Individual Factors on Increased PaCO2 during Immersed Prone Exercise at 4.7 ATA” – Original Research Poster
    Undersea and Hyperbaric Medical Society Annual Scientific Meeting, Salt Lake City, UT 2008
  7. “PGC-1a and the mitochondrial antioxidant response during sepsis” – Original Research Presentation, Best of Abstracts – Basic Science. American Society of Anesthesiologists Annual Meeting, Chicago, IL 2011

Jennifer Hauck, MD
As an undergraduate I assisted in designing and implementing various observational cross-sectional and prospective cohort studies on addictive behaviors.  After college, I worked at UCSD department of psychiatry where I assisted in the management of a multi-center twin study on ageing.  I then managed the Aids Malignancy Research Consortium clinical trials at the UCSD cancer center.  In medical school, I studied the heart rate and blood pressure variability in syncopal patients with a pediatric cardiologist.  I most recently wrote a review of the current literature on whether anesthesia in non-cardiac surgery promotes cognitive decline.  My goal for residency is to direct my enthusiasm for research to conduct observational retrospective and prospective studies of various critical care interventions using clinical informatics.  My hope is that the increasing use of informatics in the critical care arena will facilitate translational research and a more timely improvement in health outcomes.

Selected Abstracts & Publications:

  1. Nowak, J.A., Ocon, A.., Taneja, I., Medow, M.S., & Stewart, J.S. (2008). Multiresolution wavelet analysis of time-dependent physiological responses in syncopal youths.  American Journal of Physiology – Heart and Circulatory Physiology, 296, H171-H179.
  2. Nowak, J.A., Roberson-Nay, R., Strong, D.R., Bucceri, J., & Lejuez, C.W. (2003). Using item response theory in the development and validation of the College-Oriented Eating Disorders Screen (COEDS).  Eating Behaviors, 4, 346-361.

Thomas Hopkins, MD
My previous research focused on utilizing existing noninvasive and invasive monitoring to develop algorithms for predicting patient outcome in the pediatric intensive care unit.  I am currently working on a multi-disciplinary project that involves leveraging anesthesia information management systems to support the development of computerized patient safety initiatives, quality improvement metrics, and healthcare business intelligence models.

Selected Abstracts & Publications:

Peer-reviewed Publications

  1. Hopkins TJ. Local anesthetic adjuvants in regional anesthesia. Website Publication: American Society of Regional Anesthesia & Pain Medicine. 2010.
  2. Weinberg G, Hopkins TJ. Developing an Educational Tool for Managing Local Anesthetic Systemic Toxicity. APSF Grant Publication. 2011.

Peer-reviewed Publications in Process:

  1. Hopkins TJ, Frederick HJ. Reviewing user compliance with required times and pqri events following modification of the user interface of anesthesia information management systems.
  2. Hopkins TJ, MacLeod DB. Unrecognized retained lumbar drain following neurosurgery resulting in atypical spinal headache.
  3. Hopkins TJ, Mark JB, Taekman JM. Lipid Emulsion Therapy: current treatment modalities for local anesthetic-induced cardiac arrest during regional anesthesia.

Selected Abstracts and Conference Proceedings:

  1. Hopkins T, Taekman J.  Workshop on Practical Simulator Training with a View Towards MOCA for Society for Ambulatory Anesthesiology, American Society of Anesthesiologist Annual Meeting, Orlando, Florida, October 19, 2008.
  2. Hopkins T, Runyon S, Lucignano A, Ikeda K, Macleod D. Comparison of temperature changes of three co2 absorbents when exposed to three volatile agents. Anesthesiology 2010; asaabstracts.com; A084.
  3. Runyon S, Hopkins T, Ikeda K, Barnette J, Macleod D. Effect of the state of hydration of carbon dioxide (co2) absorbent upon weight changes of canisters. Anesthesiology 2010; asaabstracts.com; A090.
  4. Ikeda K, MacLeod D, Hopkins T, Runyon S, Shaw A. Comparison of compound A production by three different carbon dioxide absorbents. Anesthesiology 2010; asaabstracts.com; A1693.
  5. MacLeod D, Ikeda K, Runyon S, Hopkins T, Shaw A. Comparison of absorption of volatile anesthetic agents by three different carbon dioxide absorbents. Anesthesiology 2010; asaabstracts.com; A1168.
  6. Hopkins T, Clarke C, Buchheit T, Lindsay D.  Inter-Rater Reliability of the Durham Pain Investigation Group (DPIG) Post-Amputation Pain Algorithm (PAPA): A Feasibility Study. American Society of Anesthesiologists Annual Meeting, Chicago, IL 2011.
  7. Hopkins T, Runyon S, Ikeda K, Macleod D. Comparison of Anesthetic Agent Adsorption by CO2 Absorbents MicroPore Lithium and Amsorb Plus. American Society of Anesthesiologists Annual Meeting, Chicago, IL 2011.
  8. Hopkins T, Frederick H. Leveraging Anesthesiology Information Management Systems (AIMS) in Support of Improving Financial Effectiveness in the Perioperative Environment. American Society of Anesthesiologists Annual Meeting, Chicago, IL 2011.
  9. Frederick H, Hopkins T. Efficacay of a Simple Anesthesiology Information Management Systemy (AIMS) Initiative to Support Documentation Completeness. American Society of Anesthesiologists Annual Meeting, Chicago, IL 2011.
  10. Hopkins T, Murray Christopher, Muir H. Leveraging Anesthesia Information Management Systems (AIMS) in Support of Optimization of Perioperative Resource Utilization. American Society of Anesthesiologists Annual Meeting, Chicago, IL 2011.
  11. Hopkins, T, Murray Christopher, Muir H. Use of a Multidisciplinary Drug Shortage Response Team (MDSRT) to Prevent Adverse Impact From a Succinylcholine Shortage. American Society of Anesthesiologists Annual Meeting, Chicago, IL 2011

Rebecca Klinger, MD, MS
My graduate research was in biomedical engineering and involved two distinct topics: tissue engineering of vascular grafts for coronary artery bypass grafting and the electrical connectivity of donor cells used in cellular cardiomyoplasty to host cardiomyocytes via in vitro optical mapping of membrane voltage propagation. I have also completed a study in clinical anesthesia that focused on delineating the hemodynamic consequences of dexmedetomidine use in over 15,000 non-cardiac surgical cases performed at Duke.

Selected Abstracts & Publications:

  1. Klinger, RY., White, WD., Hale, B., Habib, AS., Bennett-Guerrero, E. “Hemodynamic impact of dexmedetomidine administration in 15,656 non-cardiac surgical cases.” Journal of Clinical Anesthesiology, 2012 (accepted for publication)
  2. Klinger, RY., Pedrotty, DM., Kirkton, RD., Bursac, N. “Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes.” Cardiovascular Research 83(4): 688-697, 2009.
  3. Pedrotty, DM., Klinger, RY., Badie, N., Hinds, S., Kardashian, A., Bursac, N. “Structural coupling of cardiomyocytes and non-cardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay” American Journal of Physiology – Heart and Circulatory Physiology 295: H390-H400, 2008.
  4. Klinger, RY., Blum, JL., Hearn, B., Lebow, B., Niklason, LE. “Relevance and safety of telomerase for human tissue engineering.” Proceedings of the National Academy of Sciences of the United States of America 103(8): 2500-2505, 2006.

Jacob Nadler, MD, PhD
My previous thesis work investigated the sensory processing of visual information.  The capacity of the visual system to perceive depth is critical for any observer who wishes to meaningfully interact with their surroundings.  Using single-unit electrophysiology and a virtual-reality system, we studied the activity of individual neurons in response to concurrent visual stimulation and physical movement.  Our experiments uncovered many single neurons that likely play a role in creating a general representation of three-dimensional space.

Selected Abstracts & Publications

  1. J.W. Nadler, M. Nawrot, D.E. Angelaki, and G.C. DeAngelis.  MT neurons combine visual motion with a smooth eye movement signal to code depth-sign from motion parallax.  Neuron 63(4), 523-532. (2009)
  2. J.W. Nadler, D.E. Angelaki, and G.C. DeAngelis.  A neural representation of depth from motion parallax in macaque visual cortex.  Nature 452, 642-645. (2008)

Quintin Quinones, MD, PhD, Academic Chief Resident
My doctoral research focused on elective therapeutic targeting of tumors through the identification of differences between the homeostatic requirements of cancer and host cells.  One such difference is the manner in which cancer cells acquire energy. Using the 1-LN human prostate cancer cell line I demonstrated that we can selectively target tumor cells under conditions of hypoxia in vitro with a small molecule inhibitor selective for MCT1 or with RNA interference of MCT1.  We also demonstrated MCT1 expression in sections of human prostate tumors to validate MCT1 as a target in prostate cancer.  I am currently most interested in the molecular mechanisms involved in the development of and recovery from Multi-Organ Dysfunction Syndrome.   I have not ruled out other fields of study and I am currently exploring the literature of various research fields in Anesthesiology for the best fit for my resident and fellow research.

Annemarie Thompson, MD

Welcome to the Duke Anesthesiology Residency Program! As the program’s director, I have the privilege to lead, support, and mentor outstanding young physicians in our residency program. I am equally honored to work with the Duke Anesthesiology faculty, internationally known for its peerless clinicians, unparalleled education, and groundbreaking research. The Triangle (Durham-Raleigh-Chapel Hill area) is well known for its major universities, Research Triangle Park, baseball, barbecue, and of course, basketball. But you might be pleasantly surprised by the less well-known advantages of living and working in the area when you visit Duke. For medical students seeking world-class training in a challenging but supportive environment, I cannot imagine a better place to begin your journey. – Annemarie Thompson, MD

Watch this video to learn why our rising CA-1 residents wanted to Match with the Duke Anesthesiology Residency Program!

Contact Us

Jessica Burkhart
Residency Program Coordinator
Department of Anesthesiology
Office: 919-681-3811
jessica.burkhart@duke.edu

Shelby Schultz
Junior Program Coordinator
Department of Anesthesiology
Office: 919-681-2924
shelby.schultz@duke.edu