Ashraf S. Habib, MBBCh, MSc, MHSc, FRCA
My research interest focuses on optimizing outcomes in the perioperative period and in obstetric patients. Recent studies have addressed multiple areas including opioid sparing analgesic adjuncts in the management of acute pain, development of an optimal strategy to manage postoperative nausea and vomiting, assessing risk factors for respiratory depression in the perioperative period, use of non invasive techniques to assess cardiac output in the parturient, and optimizing maternal hemodynamics, vasopressor support and antiemetic management in women undergoing cesarean section.
Ru-Rong Ji, PhD
The main goal of the Sensory Plasticity Laboratory is to identify novel molecular and cellular mechanisms that underlie the genesis of chronic pain. Current research includes pathogenesis of pain via neural-glial interactions, resolution of pain by anti-inflammatory and pro-resolution mediators, and molecular mechanisms of itch. We believe that tackling the mechanisms of pain induction and resolution will lead to the development of novel therapeutics for chronic pain and itch.
Stephen Klein, MD
Our research interests are focused on developing novel methods of regional anesthesia, continuous catheter techniques and strategies to advance outpatient anesthesia. Recent projects involve new device development, database analysis and mechanisms of peripheral nerve block.
Joseph P. Mathew, MD, MHSc, MBA
My primary research focus is on identification of risk factors for and prevention of neurocognitive dysfunction after cardiac surgery. Current projects assess the relationship between metabolomic expression within the cerebral circulation and postoperative neurocognitive function, evaluate the association between genotype and neurocognitive outcome, and apply function magnetic resonance imaging to assess cognitive injury after surgery. Additional areas of research interest include prediction and treatment of atrial fibrillation following cardiac surgery and perioperative transesophageal echocardiography.
Richard E. Moon, MD, CM, MSc, FRCP(C), FACP, FCCP
My research encompasses the physiology of extreme environments (altitude and diving), perioperative respiratory function and monitoring of organ function during hypovolemia. Present investigations include monitoring cardiac and vascular effects of immersed exercise, with the aim of understanding and preventing pulmonary edema during swimming and diving. Other investigations include the use of enteral monitoring to detect bowel hypoxia during hypovolemia and application of fractal analysis to heartbeat and respiratory pattern, with the aim of developing noninvasive techniques for predicting opioid-induced respiratory depression and hypovolemic shock.
Wulf Paschen, PhD
Our research is focused on understanding the mechanisms of neuronal cell death in cerebral ischemia and stroke. We have a special interest in post-translational protein modifications by small ubiquitin-like modifier (SUMO), which is dramatically activated after cerebral ischemia. Our goal is to elucidate the role of the SUMO conjugation pathway for the fate of post-ischemic neurons, using biochemical and molecular biological tools.
Mihai V. Podgoreanu, MD, FASE
Our laboratory uses evolutionary and systems biology approaches to understand the mechanisms responsible for perioperative cardiovascular adverse events following cardiac surgery. We employ various genomic technologies to characterize and identify evolutionarily conserved myocardial responses to perioperative stress in two animal models of cardiac surgery (rat and pig) and in human patients undergoing cardiac surgery. A parallel line of collaborative investigation explores the genetic basis for the progression and severity of vein graft disease and major adverse cardiac events after coronary bypass surgery using whole-genome association analysis.
Mark Stafford-Smith, MD, CM, FRCPC, FASE
The focus of my research is towards the understanding and prevention of acute kidney injury after cardiac and other major surgeries. Secondary interests include the study of analgesic strategies after cardiothoracic surgical procedures, performance of clinical trials, and perioperative transfusion and hemostasis.
Madhav Swaminathan, MD, FASE, FAHA
My research interests focus on acute kidney injury (AKI) after cardiac surgery. We place a special emphasis on developing a small-animal model of AKI and determine mechanisms of renal salvage through endogenous repair and regeneration processes. An additional area of research interest is in validating new techniques of myocardial tissue characterization using transesophageal echocardiography in adults undergoing cardiac surgery.
Jeffrey M. Taekman, MD
My research interests cover a broad range of topics surrounding simulation, education, and patient safety. Recent work includes using virtual environments for healthcare education and training, measuring healthcare team performance, and improving the safety and quality of clinical trials. Other projects involve the use of advanced informatics in healthcare and healthcare education.