PEGASUS Publications

Podgoreanu MV, Schwinn DA. New paradigms in cardiovascular medicine – Emerging technologies and practices: Perioperative genomics. J Am Coll Cardiol, Dec, 2005; 1965-77
Stafford-Smith M, Podgoreanu M, Swaminathan M, Phillips-Bute B, Mathew JP, Hauser EH, Winn MP, Milano C, Nielsen DM, Smith M, Morris R, Newman MF, Schwinn DA for the PEGASUS Investigators. Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery. Am J Kidney Dis 2005; 45: 519-530
Welsby IJ, Podgoreanu MV, Phillips-Bute B, White WD, Nielsen DM, Mathew JP, Smith PK, Newman MF, Schwinn DA, Stafford-Smith M, for the PEGASUS Investigators. Genetic basis for bleeding after cardiac surgery – A preliminary report. J Thromb Haemost 2005; 3: 1206-1213
Grocott HP, White WD, Morris RW, Podgoreanu MV, Mathew JP, Schwinn DA, Newman MF, for the PEGASUS Investigators. Genetic polymorphisms and the risk of stroke after cardiac surgery. Stroke 2005 Sep;369:1854-8
Podgoreanu MV, Michelotti GA, Sato Y, Smith MP, Lin S, Grocott HP, Booth JV, Schwinn DA. Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of pro-inflammatory genes. J Thorac Cardiovasc Surg 2005; 130 : 330-339
Moretti EW, Morris RW, Schwinn DA, Podgoreanu MV, Newman MF, Bennett E, Moulin VG, Mba UU, Laskowitz DT, for the PEGASUS Investigators. APOE polymorphism is associated with sepsis risk in surgical patients. Crit Care Med; 2005; 33(11); 2521-2526
Podgoreanu MV, Mathew JP. Prophylaxis against postoperative atrial fibrillation: current progress and future directions. JAMA 2005; 294(24): 3093-100
Podgoreanu MV, White WD, Morris RW, Mathew JP, Stafford-Smith M, Welsby IJ, Grocott HP, Milano CA, Newman MF, Schwinn DA; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction following cardiac surgery. Circulation 2006; 114(Suppl 1):275-281
Newman MF, Mathew JP, Grocott HP, Mackensen GB, Monk T, Welsh-Bohmer KA, Blumenthal JA, Laskowitz DT, Mark DB. Central nervous system injury associated with cardiac surgery. Lancet 2006; 368:694-703
Moretti EW, Newman MF, Muhlbaier LH, Whellan D, Petersen RP, Rossignol D, McCants CB Jr, Phillips-Bute B, Bennett-Guerrero E. Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery. Arch Surg 2006;141(7):637-41
Swaminathan M, Stafford-Smith M. Renal dysfunction after vascular surgery. Curr Opin Anaesthesiol 2003;16(1):45-51
Grocott HP. Genetics and outcome after cardiac surgery. J Extra Corpor Technol 2006;38(1):49-51
Yoshitani K, de Lange F, Ma Q, Grocott HP, Mackensen GB. Reduction in air bubble size using perfluorocarbons during cardiopulmonary bypass in the rat. Anesth Analg 2006;103(5):1089-93
Jungwirth B, Mackensen GB, Blobner M, Neff F, Reichart B, Kochs EF, Nollert G. Neurologic outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats: description of a new model. J Thorac Cardiovasc Surg 2006;131(4):805-12
Grocott HP, Mackensen GB. Apolipoprotein E genotype and S100beta after cardiac surgery: is inflammation the link? Anesth Analg 2005;100(6):1869-70
Jungwirth B, Gordan ML, Blobner M, Schmehl W, Kochs EF, Mackensen GB. Xenon impairs neurocognitive and histologic outcome after cardiopulmonary bypass combined with cerebral air embolism in rats. Anesthesiology 2006;104(4):770-6
Dieleman JM, de Lange F, Houston RJ, Biessels GJ, Bar PR, Mackensen GB, Grocott HP, Kalkman CJ. Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat. Life Sci 2006; 79(6):551-8
Schambra UB, Mackensen GB, Stafford-Smith M, Haines DE, Schwinn DA. Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. Neuroscience 2005;135(2):507-23
Mathew JP, Rinder HM, Smith BR, Newman MF, Rinder CS. Transcerebral platelet activation after aortic cross-clamp release is linked to neurocognitive decline. Ann Thorac Surg 2006;81(5):1644-9
Zhang Q, Morris RW, Mathew JP, Schwinn DA, Newman MK, Podgoreanu MV. Clinical, procedural and genetic determinants of QTc prolongation following cardiac surgery. 2006. Abstract to the Society of Cardiovascular Anesthesiologist’s national meeting.