Clinical Faculty

John J. Freiberger, MD, MPH

Assistant Professor of Anesthesiology

Department:
Anesthesiology

Division:
Anesthesiology

Mailing Address:
DUMC 3823 Durham, NC 27710

Appointment Telephone:
919-684-6726

Office Telephone:
919-684-6726

Fax:
919-684-6002

Training:
MD, University of Texas Southwestern Medical School, 1979

Fellowship:
Critical Care Medicine, Massachusetts General Hospital, 1984
Hyperbaric Medicine, Duke University Medical Center, 2001

Residency:
Anesthesiology, Massachusetts General Hospital, 1983

Clinical Interests:
Hyperbaric medicine, diving medicine, neuroprotection, wound healing

Research Interests:
Dr Freiberger works on the translation of basic science research on reactive oxygen species signaling into clinical practice involving hyperbaric oxygen (HBO).  He has performed animal experiments in the use of HBO for ischemic preconditioning and he is currently funded to conduct a randomized controlled trial of the use of HBO for the treatment of bisphosphonate-induced osteonecrosis of the jaw. The mechanisms of action for HBO in the treatment of: diabetic wounds, bony and soft tissue radionecrosis and decompression sickness are also areas of his inquiry.  Dr Freiberger also does basic epidemiological research into accidents and injuries associated with diving, high altitude exposure and other adverse conditions associated with extreme environments. Dr. Freiberger directs the fellowship program at the Duke Center for Hyperbaric Medicine and Environmental Physiology.

Publications:
Wester TE, Cherry AD, Pollock NW, Freiberger JJ, Natoli MJ, Schinazi EA, Doar PO, Boso AE, Alford EL, Walker AJ, Uguccioni DM, Kernagis D, Moon RE. Effects of head and body cooling on hemodynamics during immersed prone exercise at 1 ATA. J Appl Physiol. 2009 Feb;106(2):691-700.

Vann RD, Denoble PJ, Howle LE, Weber PW, Freiberger JJ, Pieper CF. Resolution and severity in decompression illness. Aviat Space Environ Med. 2009 May;80(5):466-71.

Freiberger JJ. Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2009 May;67(5 Suppl):96-106.

Freiberger JJ, Yoo DS, de Lisle Dear G, McGraw TA, Blakey GH, Padilla Burgos R, Kraft K, Nelson JW, Moon RE, Piantadosi CA. MultiModality Surgical and Hyperbaric Management of Mandibular Osteoradionecrosis. Int J Radiat Oncol Biol Phys. 2009 Mar 26.

Cherry AD, Forkner IF, Frederick HJ, Natoli MJ, Schinazi EA, Longphre JP, Conard JL, White WD, Freiberger JJ, Stolp BW, Pollock NW, Doar PO, Boso AE, Alford EL, Walker AJ, Ma AC, Rhodes MA, Moon RE. Predictors of increased PaCO2 during immersed prone exercise at 4.7 ATA. J Appl Physiol. 2009 Jan;106(1):316-25.

Vann RD, Moon RE, Freiberger JJ, Denoble PJ, Dear GL, Stolp BW, Massey EW. Decompression illness diagnosis and decompression study design. Aviat Space Environ Med. 2008 Aug;79(8):797-8.

Vann RD, Pollock NW, Freiberger JJ, Natoli MJ, Denoble PJ, Pieper CF. Influence of bottom time on preflight surface intervals before flying after diving. Undersea Hyperb Med. 2007 May-Jun;34(3):211-20.

Longphre JM, Denoble PJ, Moon RE, Vann RD, Freiberger JJ. First aid normobaric oxygen for the treatment of recreational diving injuries.  Undersea Hyperb Med.  2007 Jan-Feb;34(1):43-9.

Freiberger JJ, Padilla-Burgos R, Chhoeu AH, Kraft KH, Boneta O, Moon RE, Piantadosi CA. Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series.  J Oral Maxillofac Surg.  2007 Jul;65(7):1321-7.

Freiberger JJ, Suliman HB, Sheng H, McAdoo J, Piantadosi CA, Warner DS. A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats. Brain Res. 2006 Feb 23;1075(1):213-22.

Freiberger JJ, Lyman SJ, Denoble PJ, Pieper CF, Vann RD. Consensus factors used by experts in the diagnosis of decompression illness. Aviat Space Environ Med. 2004 Dec;75(12):1023-8.

Freiberger J, Lyman S, Denoble PJ, Pieper CF, Vann RD. Consensus factors used by experts in the diagnosis of decompression illness. Aviat Space Environ Med. 2004;75:1023-1028.

Freiberger J, Coulombe K, Suliman H, Carraway M, Piantadosi C. Superoxide dismutase responds to hyperoxia in rat hippocampus. Undersea Hyperb Med. 2004 Summer;31(2):227-32.

Cronje FJ, Carraway MS, Freiberger JJ, Suliman HB, Piantadosi CA. Carbon monoxide actuates o(2)-limited heme degradation in the rat brain. Free Radic Biol Med. 2004 Dec 1;37(11):1802-12.

Whittington D, Matsui-Santana O, Freiberger JJ, Van Houtven G, Pattanayak S. Private demand for a HIV/AIDS vaccine: evidence from Guadalajara, Mexico. Vaccine. 2002 Jun 7;20(19-20):2585-91.

Freiberger JJ, Denoble PJ, Pieper CF, Uguccioni DM, Pollock NW, Vann RD. The relative risk of decompression sickness during and after air travel following diving. Aviat Space Environ Med. 2002 Oct;73(10):980-4.

Freiberger JJ, Marsicano TH. Alprazolam withdrawal presenting as delirium after cardiac surgery. J Cardiothorac Vasc Anesth. 1991 Apr;5(2):150-2.

Freiberger JJ. An unusual presentation of an airway tear. Anesthesiology. 1984 Aug;61(2):204-6.