Clinical Faculty

G. Burkhard Mackensen, MD, PhD

Associate Professor of Anesthesiology

Department:
Anesthesiology

Division:
Anesthesiology

Mailing Address:
DUMC 3094 Durham, NC 27710

Appointment Telephone:
919-681-6944

Office Telephone:
919-684-6025

Fax:
919-681-8993

Training:
MD, University of Hamburg Faculty of Medicine (Germany), 1994

Fellowship:
Cardiothoracic Anesthesia, Duke University Medical Center, 1998-2000
Intensive Care Medicine, Technical University of Munich (Germany), 2001-2002

Residency:
Anesthesiology, Technical University of Munich (Germany), 1997

Clinical Interests:
Critical care medicine and cardiothoracic anesthesiology, transesophageal echocardiography

Research Interests:
My major research interests focus on the investigation of mechanisms and potential strategies for therapy related to cerebral injury following CPB and cardiac surgery. For the preclinical investigation of these topics, we utilize a rat modell of cardiopulmonary bypass that allows the longterm recovery of the animals. Future areas of focus will include the inflammatory response following CPB, with links to cerebral gene and protein expression, proteomics and possible therapeutic interventions. In addition, we are expanding work with a newly developed model of deep hypothermic cardiac arrest (DHCA) in the rat. This area (i.e. DHCA) has long been lacking a small animal model that allows long-term testing and evaluation of neurocognitive function; this novel model will promote numerous lines of research. Both models (DHCA and CPB) serve to investigate improved modes of anticoagulation during CPB as well as renal impairment associated with CPB/DHCA. Lastly, I am interested in the neurobehavioral testing of rodents and have been involved in the adaptation of the Hole-board test for the use in animals with cerebral injury. This test represents a more meaningful neurocognitive test compared to the Morris water maze and includes numerous cognitive outcome parameters.

Publications:
Jungwirth B, Mackensen GB, Blobner M, Neff F, Reichart B, Kochs EF, Nollert G. Neurologic outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats: description of a new model.  J Thorac Cardiovasc Surg.  2006131:805-812.

Jungwirth B, Gordan ML, Blobner M, Schmehl W, Kochs EF, Mackensen GB. Xenon impairs neurocognitive and histologic outcome after cardiopulmonary bypass combined with cerebral air embolism in rats.  Anesthesiology.  2006;104:770-776.

Mackensen GB, Ti LK, Phillips-Bute BG, Mathew JP, Newman MF, Grocott HP,  . Cerebral embolization during cardiac surgery: impact of aortic atheroma burden.  Br J Anaesth.  2003;91:656-661.

Mackensen GB, Sato Y, NellgÃ¥rd B, Pineda J, Newman MF, Warner DS, Grocott HP. Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat.  Anesthesiology.  2001;95:1485-1491.

Mackensen GB, Patel M, Sheng H, Calvi CL, Batinic-Haberle I, Day BJ, Liang LP, Fridovich I, Crapo JD, Pearlstein RD, Warner DS. Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant.  J Neurosci.  2001;21:4582-4592.

Mackensen GB, NellgÃ¥rd B, Miura Y, Chu CT, Dexter F, Pearlstein RD, Warner DS. Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat.  Anesthesiology.  1999;90:873-881.