Clinical Faculty

Anthony M. Roche, MB ChB

Assistant Professor of Anesthesiology

Department:
Anesthesiology

Division:
Anesthesiology

Mailing Address:
DUMC 3094 Durham, NC 27710

Appointment Telephone:
919-681-9660

Office Telephone:
919-681-9660

Fax:
919-681-8994

Training:
MB ChB, Stellenbosch University Faculty of Health Sciences (South Africa), 1993

Fellowship:
Liver Transplantation Anaesthesia, Royal Free Hospital, London (United Kingdom), 2002
Cardiothoracic Anaesthesia, Royal Brompton and Harefield Hospitals (United Kingdom), 2003

Residency:
University College Hospital, North Thames Central School of Anaesthesia (United Kingdom), 2003

Clinical Interests:
Anesthesia for the high-risk surgical patient, hepatobiliary and transplant anesthesia, perioperative coagulation disorders, blood conservation, bloodless medicine

Research Interests:
Coagulation and hemostasis, including perioperative monitoring.
Intravenous fluid therapy and volume resuscitation.
Outcome effects of perioperative coagulation dysfunction.
Blood conservation.
Perioperative endothelial dysfunction.

Publications:
Roche AM, James MFM. Fluid therapy in organ transplantation. Current Opinion in Organ Transplantation. 2007;12:281-6.

Roche AM, Gan TJ. Perioperative Goal-Directed Fluid Therapy: Perceived or Real Benefit?  US Surgery, 2007 Editorial.
http://www.touchbriefings.com/cdps/cditem.cfm?nid=2742&cid=5



Welsby IJ, Jiao K, Ortel TL, Brudney CS, Roche AM, Bennett-Guerrero E, Gan TJ. The kaolin-activated Thrombelastograph predicts bleeding after cardiac surgery. J Cardiothorac Vasc Anesth. 2006 Aug;20(4):531-5.

Roche AM, James MF, Grocott MP, Mythen MG. Just scratching the surface: varied coagulation effects of polymer containers on TEG variables. Eur J Anaesthesiol. 2006 Jan;23(1):45-9.

Roche AM, James MF, Bennett-Guerrero E, Mythen MG. A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluids. Anesth Analg. 2006 Apr;102(4):1274-9.

McLeod A, Roche A, Fennelly M. Potential role for ultrasonography to assist epidural insertion in scoliosis patients. Canadian Journal of Anesthesia 2005;52: 717-720.

Roche AM, Mythen MG, James MF. Effects of a new modified balanced hydroxyethyl starch preparation (Hextend) on measures of coagulation. Br J Anaesth. 2004 Jan;92(1):154-5.

James MF, Roche AM. Dose-response relationship between plasma ionized calcium concentration and thrombelastography. J Cardiothorac Vasc Anesth. 2004 Oct;18(5):581-6.

James MF, Latoo MY, Mythen MG, Mutch M, Michaelis C, Roche AM, Burdett E. Plasma volume changes associated with two hydroxyethyl starch colloids following acute hypovolaemia in volunteers. Anaesthesia. 2004 Aug;59(8):738-42.

Ruttmann TG, Roche AM, Gasson J, James MF. The effects of a one unit blood donation on auto-haemodilution and coagulation. Anaesth Intensive Care. 2003 Feb;31(1):40-3.

Roche AM, James MF, Grocott MP, Mythen MG. Citrated blood does not reliably reflect fresh whole blood coagulability in trials of in vitro hemodilution. Anesth Analg. 2003 Jan;96(1):58-61, table of contents.

E Burdett, AM Roche, MG Mythen.  Hyperchloremic Acidosis: Pathophysiology and Clinical Impact. Transfusion Alternatives in Transfusion Medicine 2003;5:390-396

AM Roche, MFM James. Watering down the clots, or are we? Trauma 2003;5:235-44

Roche AM, James MF, Grocott MP, Mythen MG. Coagulation effects of in vitro serial haemodilution with a balanced electrolyte hetastarch solution compared with a saline-based hetastarch solution and lactated Ringer's solution. Anaesthesia. 2002 Oct;57(10):950-5.