The DREAM Innovation Grant (DIG) supports innovative high-risk, and potentially high-reward investigations to accelerate anesthesia and pain management research. Our goal is to raise $90,000, which will allow us to fund at least three $30K DIG recipients in 2015. The winners of this grant will be announced in October 2014. To date, we have raised $81,500 towards our goal!
Congratulations to the Duke Anesthesiology Racing Team for finishing in first for fundraising out of 24 teams at this year’s ASA Run for the Warriors 5K Race in San Francisco! Under the leadership of Dr. Ryan Fink, Duke surged into first by raising $9,300.00. The money raised will go towards supporting U.S. service members and their families who have been affected by injuries or death to defend our country.
ChrisDuke wins first place for the third year in a row at the ASA Run for the Warriors
David Warner, MD presenting the 2014 Dream Innovation Grant (DIG) winners at the Duke Alumni reception in San Franscisco, CA.
Miles Berger, MD, PhD accepting his certificate as one of the three DIG winners.
Dr. Warner and Dr. Berger during the 2014 DIG awards presentation.
Thomas J. Van de Ven, MD, PhD accepting his 2014 DIG certificate from Mark F. Newman, MD.
2014 DIG recipient, Zhiquan Zhang, PhD
The three 2014 DIG recipients (L ro R): Drs. Zhan, Berger and Van de Ven
After careful consideration, the DIG Application Review Committee, comprised of: Dr. Manuel Fontes, Dr. Tong-Joo Gan , Dr. Ru-Rong Ji, Dr. Joseph Mathew, Dr. Richard Moon, Dr. Mark Newman, Dr. Mihai Podgoreanu, Dr. Andrew Shaw, Dr. Mark Stafford-Smith, and Dr. David Warner, selected three research studies to receive the grant.
Chris KeithCongratulations to our three, 2014 DIG winners!
Pharmacogenomics of β-blockers: Implication for Postoperative Atrial Fibrillation
Miklos Kertai, MD, PhD
The purpose of our study is to identify genetic variations in human genes that are responsible for modulating the efficacy of beta-blockers for the prevention of postoperative atrial fibrillation. For the purposes of the present study, we are using isolated DNA and human atrial tissue from patients who underwent coronary artery bypass grafting (CABG) surgery at Duke University Medical Center.
Since the initiation of the study, we have: 1) identified a group of patients from our clinico-genetic database with clinical information on beta-blocker use and atrial fibrillation who underwent CABG surgery, 2) selected patients with available DNA and atrial tissue, 3) processed and isolated messenger RNA from atrial tissue, and 4) submitted the isolated messenger RNAs for gene expression profiling. The results of the gene expression profiling will allow us to measure the activity of genes that might be associated with an increased risk for postoperative atrial fibrillation and reduced efficacy of beta-blockers.
Our next step in the study is to allocate DNAs of the same patients for whom we have isolated messenger RNA from atrial tissues. Subsequently, the DNAs will be analyzed for the presence and frequency of variations that might be associated with an increased risk for postoperative atrial fibrillation and reduced efficacy of Pharmacogenomics of beta-blockers.
Chris KeithSpring 2013 DIG Report: Miklos Kertai, MD, PhD
Neurointerventional Regional Anesthesia to Improve Hand Rehabilitation in Stroke
Steve Melton, MD
This collaborative research project between investigators from anesthesiology, physical therapy, and neurology is proceeding as planned. Initial groundwork, preparation, and coordination have occurred to facilitate successful recruitment, enrollment and implementation of the study design and data collection. Additionally, the group is in the process of preparing multiple manuscripts related to our preliminary fMRI investigation in healthy, human subjects. Data from this work is being used to guide implementation of the current project in the stroke-affected population.
Chris KeithSpring 2013 DIG Report: Steve Melton, MD