Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
Ji RR, Nackley A, Huh Y, Terrando N, Maixner W.
Anesthesiology. 2018 Feb 19. [Epub ahead of print]
PMID: 29462012

Circulating Omentin-1 and Chronic Painful Temporomandibular Disorders.
Harmon JB, Sanders AE, Wilder RS, Essick GK, Slade GD, Hartung JE, Nackley AG.
J Oral Facial Pain Headache. 2016 Summer;30(3):203-209.
PMID: 27472522

Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral β-Adrenergic Receptors.
Ciszek BP, O’Buckley SC, Nackley AG.
Anesthesiology. 2016 May;124(5):1122-35.
PMID: 26950706

Novel Intrathecal and Subcutaneous Catheter Delivery Systems in the Mouse
Oladosua FA, Ciszek BP, O’Buckley SC, Nackley AG
J Neurosci Methods. 2016 May 1;264:119-28. Epub 2016 Mar 11.
PMID: 26976722

Chronic Pain: Translating Discoveries Into Treatments.
Nackley A.
International Innovation. 2015 June;185:56-58.

Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia.
Oladosu FA, Conrad MS, O’Buckley SC, Rashid NU, Slade GD, Nackley AG.
PLoS One. 2015 Aug 13;10(8):e0135711.  eCollection 2015.
PMID: 26270813

Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.
Oladosu FA, Maixner W, Nackley AG.
Mayo Clin Proc. 2015 Aug;90(8):1135-51. Review.
PMID: 26250730

Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation.
Hartung JE, Eskew O, Wong T, Tchivileva IE, Oladosu FA, O’Buckley SC, Nackley AG.
Brain Behav Immun. 2015 Nov;50:196-202. Epub 2015 Jul 15.
PMID: 26187567

MicroRNA expression profiles differentiate chronic pain condition subtypes.
Ciszek BP, Khan AA, Dang H, Slade GD, Smith S, Bair E, Maixner W, Zolnoun D, Nackley AG.
Transl Res. 2015 Dec;166(6):706-720.e11. Epub 2015 Jun 24.
PMID: 26166255

Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients.
Applebaum E, Nackley AG, Bair E, Maixner W, Khan AA.
J Endod. 2015 Aug;41(8):1214-8. Epub 2015 Jun 14.
PMID: 26081267

Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.
Smith SB, Reenilä I, Männistö PT, Slade GD, Maixner W, Diatchenko L, Nackley AG.
Pain. 2014 Nov;155(11):2390-9. Epub 2014 Sep 16.
PMID: 25218601

β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines.
Hartung JE, Ciszek BP, Nackley AG.
Pain. 2014 Jul;155(7):1346-55. Epub 2014 Apr 13.
PMID: 24727346

Excess risk of temporomandibular disorder associated with cigarette smoking in young adults.
Sanders AE, Maixner W, Nackley AG, Diatchenko L, By K, Miller VE, Slade GD.
J Pain. 2012 Jan;13(1):21-31. Epub 2011 Oct 26.
PMID: 22036516

Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness.
Slade GD, Conrad MS, Diatchenko L, Rashid NU, Zhong S, Smith S, Rhodes J, Medvedev A, Makarov S, Maixner W, Nackley AG.
Pain. 2011 Dec;152(12):2802-12. Epub 2011 Oct 14.
PMID: 22000099

A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism.
Gris P, Gauthier J, Cheng P, Gibson DG, Gris D, Laur O, Pierson J, Wentworth S, Nackley AG, Maixner W, Diatchenko L.
Mol Pain. 2010 Jun 2;6:33.
PMID: 20525224

Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders.
Nackley AG, Diatchenko L.
Methods Mol Biol. 2010;617:375-93.
PMID: 20336436

Signaling pathways mediating beta3-adrenergic receptor-induced production of interleukin-6 in adipocytes.
Tchivileva IE, Tan KS, Gambarian M, Nackley AG, Medvedev AV, Romanov S, Flood PM, Maixner W, Makarov SS, Diatchenko L.
Mol Immunol. 2009 Jul;46(11-12):2256-66. Epub 2009 May 23.
PMID: 19477016

Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.
Nackley AG, Shabalina SA, Lambert JE, Conrad MS, Gibson DG, Spiridonov AN, Satterfield SK, Diatchenko L.
PLoS One. 2009;4(4):e5237. Epub 2009 Apr 13.
PMID: 19365560

Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase.
Tchivileva IE, Nackley AG, Qian L, Wentworth S, Conrad M, Diatchenko LB.
Mol Pain. 2009 Mar 16;5:13.
PMID: 19291302

Genetic architecture of human pain perception.
Diatchenko L, Nackley AG, Tchivileva IE, Shabalina SA, Maixner W.
Trends Genet. 2007 Dec;23(12):605-13. Epub 2007 Nov 26. Review.
PMID: 18023497

Responses to Drs. Kim and Dionne regarding comments on Diatchenko, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006; 125: 216-24.
Diatchenko L, Slade GD, Nackley AG, Maixner W.
Pain. 2007 Jun;129(3):366-370. No abstract available.
PMID: 17851590

Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms.
Tan KS, Nackley AG, Satterfield K, Maixner W, Diatchenko L, Flood PM.
Cell Signal. 2007 Feb;19(2):251-60. Epub 2006 Sep 20.
PMID: 16996249

Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli.
Diatchenko L, Nackley AG, Slade GD, Bhalang K, Belfer I, Max MB, Goldman D, Maixner W.
Pain. 2006 Dec 5;125(3):216-24. Epub 2006 Jul 11.
PMID: 16837133

Idiopathic pain disorders–pathways of vulnerability.
Diatchenko L, Nackley AG, Slade GD, Fillingim RB, Maixner W.
Pain. 2006 Aug;123(3):226-30. Epub 2006 Jun 13. Review. No abstract available.
PMID: 16777329

Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study.
Hohmann AG, Neely MH, Piña J, Nackley AG.
J Pain. 2005 Dec;6(12):798-808.
PMID: 16326368

Basal and carrageenan-induced pain behavior in Sprague-Dawley, Lewis and Fischer rats.
Fecho K, Nackley AG, Wu Y, Maixner W.
Physiol Behav. 2005 Jun 2;85(2):177-86.
PMID: 15924913

Genetic basis for individual variations in pain perception and the development of a chronic pain condition.
Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W.
Hum Mol Genet. 2005 Jan 1;14(1):135-43. Epub 2004 Nov 10.
PMID: 15537663

Sandra O’Buckley
Lab Research Analyst I
Nackley Laboratory Manager
Office: +1-919-684-4867
Fax: +1-919-613-2324

Center for Translational Pain Medicine
Department of Anesthesiology
Duke University

1011 Snyderman Building
905 South LaSalle St.
DUMC 3094, MS #50
Durham, NC 27710

Chris KeithPublications