I am interested in the genetic and pharmocologic alterations in reduced catechol-O-methyltransferase (COMT) activity that are associated with increased pain sensitivity and likelihood of developing chronic pain disorders such as temporomandibular joint disorder. I am currently using an animal model to determine if COMT-dependent pain is transmitted via peripherally, spinally or centrally located b– adrenergic receptors. Determining a site of action for COMT-dependent pain has the propensity to broaden the understanding and treatment of chroni pain disorders, as well as clinical conditions that share common or overlapping pathologies.
2016: First-place recipient of the 24th Annual Duke Anesthesiology Academic Evening’s Excellence in the Pre-Doctoral Non-Medical Student category.
2015: Turner Award Finalist (UNC SOD Dental Research & Review Day)
2015: HHMI International Fellowship Nominee
2014: Freedland Advances Dental Eduaction Fellowship (Dental Foundation of North Carolina)
2014: Turner Award Finalist (UNC SOD Dental Research & Review Day)
2013: 2nd Place – Poster Presentation at the International Pelvic Pain Society Meeting (Orlando, FL)
2013-2015: Science Program for Excellence in Science – Member (Funded by AAAS / Science Magazine)
2013: 2nd Runner Up – Turner Award (UNC SOD Dental Research & Review Day)
2012: Merit Fellowship Recipient (UNC Doctorate Program Fellowship)
2012: Director’s Award Recipient (UNC Doctorate Program Award)
Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral β-Adrenergic Receptors.
Ciszek BP, O’Buckley SC, Nackley AG.
Anesthesiology. 2016 May;124(5):1122-35.
MicroRNA expression profiles differentiate chronic pain condition subtypes.
Ciszek BP, Khan AA, Dang H, Slade GD, Smith S, Bair E, Maixner W, Zolnoun D, Nackley AG.
Transl Res. 2015 Dec;166(6):706-720.e11. doi: 10.1016/j.trsl.2015.06.008. Epub 2015 Jun 24.
β2- and β3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines.
Hartung JE, Ciszek BP, Nackley AG.
Pain. 2014 Jul;155(7):1346-55. doi: 10.1016/j.pain.2014.04.011. Epub 2014 Apr 13.