Endogenous and exogenous opioids bind to the mu opioid receptor (MOR-1) to produce analgesia. Opioids are the most commonly prescribed class of drugs for the treatment of pain; their use, however, is accompanied by a number of deleterious side effects. One such side effect is opioid-induced hyperalgesia (OIH), a paradoxical phenomenon in which acute or chronic opioid administration creates increased pain sensitivity, or hyperalgesia, in genetically susceptible individuals. Recent evidence suggests that a MOR-1 splice variant, MOR-1K, contributes to the formulation of hyperalgesic states such as OIH.
Recently, our lab revealed that, in generally diverse strains of mice, MOR-1K gene expression paralleled pain behavior in the two most extreme strains, such that expression was decreased in mice exhibiting analgesia and increased in mice exhibiting OIH. Continuing in the same vein, my research aims to examine the MOR-1 and MOR-1K gene transcripts from three mouse strains, and determine if possible polymorphisms may be implicated in strain-specific MOR-1K gene expression and corresponding pain behavior.
2015-2016: UNC Dissertation Completion Fellowship
Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia.
Oladosu FA, Conrad MS, O’Buckley SC, Rashid NU, Slade GD, Nackley AG.
PLoS One. 2015 Aug 13;10(8):e0135711. doi: 10.1371/journal.pone.0135711. eCollection 2015.
Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.
Oladosu FA, Maixner W, Nackley AG.
Mayo Clin Proc. 2015 Aug;90(8):1135-51. doi: 10.1016/j.mayocp.2015.06.010. Review.
Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation.
Hartung JE, Eskew O, Wong T, Tchivileva IE, Oladosu FA, O’Buckley SC, Nackley AG.
Brain Behav Immun. 2015 Nov;50:196-202. doi: 10.1016/j.bbi.2015.07.014. Epub 2015 Jul 15.