Katie Kanter

Katie Kanter

Undergraduate Researcher

Duke University, Department of Anesthesiology
Center for Translational Pain Medicine
1014 Snyderman Building
905 South LaSalle Street
Durham, NC, 27710, USA
Phone: +1-919-684-9728
Fax: +1-919-613-2324
Email: katie.kanter@duke.edu

Date Joined Laboratory
October 2016


Duke 2017 Summer Neuroscience Program Fellowship Award
Title: Effects of MOR-1K Genetic Variation on Cellular Activity
Summary: Opioid induced hyperalgesia manifests as increased pain sensitivity due to acute or chronic opioid administration. A truncated variant in the mu opioid receptor, MOR-1K, has been linked to pain in human genetic studies, and shown to produce cellular excitation, resulting in hyperalgesia rather than analgesia.The Nackley Lab has identified a candidate single nucleotide polymorphism (SNP) within the enhancer box regulatory motif on MOR-1K exon 13 in CXB7/ByJ mice, that is predicted to contribute to the increased pain sensitivity observed in this variant compared to 129S6 mice. The proposed work will continue a previously unpublished study by the Nackley lab, to elucidate alterations to MOR-1K receptor function related to this SNP using a cAMP assay, and ultimately examine changes to transcriptional regulation via a luciferase assay.

Sandra O’Buckley
Lab Research Analyst I
Nackley Laboratory Manager
Email: sandra.obuckley@duke.edu
Office: +1-919-684-4867
Fax: +1-919-613-2324

Center for Translational Pain Medicine
Department of Anesthesiology
Duke University

1011 Snyderman Building
905 South LaSalle St.
DUMC 3094, MS #50
Durham, NC 27710

Chris KeithKatie Kanter