During a swim or dive have you experienced symptoms of swimming-induced pulmonary edema (SIPE)?
Have you become short of breath, coughed up pink sputum or been taken to a hospital for treatment of pulmonary edema experienced during or after a swim or dive? Doctors at the Duke University Center for Hyperbaric Medicine and Environmental Physiology are performing a research study to determine whether this can be prevented using the drug sildenafil. Triathletes, divers and swimmers who have experienced SIPE are needed to participate in this exercise study in water.
Based on preliminary studies and anecdotal evidence, sildenafil (Viagra®) taken may help prevent SIPE. This Navy funded study is designed to test the effectiveness of sildenafil.
Prior to the study, subjects will be interviewed by phone. Those who are selected will come to Duke for a physical exam, tests and orientation. There will be 2 experimental days, each requiring 2-3 hours, 7 or more days apart (it will be possible to return home between tests). On each day subjects will perform a 40-minute cycle exercise while immersed to the neck in cold water.
Subjects will be paid for completion of the study and travel expenses will be reimbursed.
Subjects must be 18-45 years of age, physically fit (be able to exercise constantly for 40 minutes), and have no physical impairment that would prevent them from participation.
For more information, please e-mail SIPEstudy@dm.duke.edu, call Mike Natoli at 919-684-6726 or visit the Sipe Prescreening Questionnaire website.
Version 1/1/2019 – USN Immersion Pulmonary Edema Study – Pro00100971