Jiahui Su, PhD

Jiahui Su, PhD
Postdoctoral Associate

Contact Information:

919-681-4710
jiahui.su@duke.edu

Background and Research Interests

I am a scientific researcher with interdisciplinary expertise in cardiovascular disease, cancer, and neuroscience. I completed my doctoral training in Pharmacology at Sun Yat-sen University (SYSU), China. During my graduate studies, I worked in Dr. Tianxin Yang's lab, focusing on the role of the (pro)renin receptor in hypertension and kidney disease. For my Ph.D. dissertation, I conducted research on investigating the interplay between atherosclerosis and ferroptosis under the mentorship of Dr. Jiahui Zhou. During my graduate studies, I developed a keen interest in the immune system’s involvement in disease, particularly in the roles of dendritic cells and T cells. To further explore this area, I joined Dr. Steven Crowley’s lab at Duke University, where I investigated the role of dendritic cells in hypertension and kidney disease. As my research in cardiovascular disease advanced, I became increasingly intrigued by the nervous system’s regulatory role in disease and its potential to serve as a critical link between various organ systems. This sparked my interest in neuron-immune interactions. In October 2023, I joined Dr. Donnelly’s lab as a postdoc to investigate neuron-immune crosstalk in head and neck squamous cell carcinoma (HNSCC). My long-term goal is to pursue an academic research career in cancer neuroscience, with a focus on the neuron-immune interactions.

Publications

  1. Su J, Hong Y, Han C, Yu J, Guan X, Zhu Y, Wang C, Ma M, Pang R, Ou J, Zhou J, Zhang Z, Ban T, Liang S. (2024). Dual action of macrophage miR-204 confines cyclosporine A-induced atherosclerosis. Br J Pharmacol (IF: 8.74)
  2. Lin Z, Lin X, Lai Y, Han C, Fan X, Tang J, Mo S, Su J, Liang S, Shang J, ] Lv F, Guo S, Pang R, Zhou J, Zhang T, Zhang R. (2022). Ponatinib modulates the metabolic profile of obese mice by inhibiting adipose tissue macrophage inflammation Front Pharmacol (IF=5.81)
  3. Lu A, Pu M, Mo S, Su J, Hu J, Lu C, Wang W, Yang T. (2022). (Pro)renin Receptor Regulates Phosphate Homeostasis in Rats via Releasing Fibroblast Growth Factor-23. Front Physiol. (IF=4.57)
  4. Hu J, Tan Y, Chen Y, Mo S, Brittin Hekking 2, Su J, Pu M, Lu A, Du Y, J David Symons, Yang T. (2022). Role of (pro)renin receptor in cyclosporin A- induced nephropathy. Am J Physiol Renal Physiol. (IF=3.38)
  5. Fu Z, Wang F, Liu X, Hu J, Su J, Lu X, Lu A, Jae Min Cho, J David Symons , Zou C, Yang T. (2021). Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor. Clin Sci (Lond) (IF=6.12)
  6. Xie S, Su J, Lu A, Lai Y, Mo S, Pu M, Yang T. (2020). Soluble (pro)renin receptor promotes the fibrotic response in renal proximal tubule epithelial cells in vitro via the Akt/β-catenin/Snail signaling pathway. Am J Physiol Renal Physiol. (IF=3.38)
  7. Z Fu, J Hu, L Zhou, Y Chen, M Deng, X Liu, J Su, A Lu, X Fu, T Yang. (2019). (Pro) renin receptor contributes to pregnancy-induced sodium-water retention in rats via activation of intrarenal RAAS and α-ENaC. Am J Physiol Renal Physiol. (IF=3.38)
  8. Z Fu, J Hu, Wang F, Su J, Lu X, Lu A, J David Symons, Tianxin Yang. (2018). The soluble (Pro) renin receptor induces endothelial cell dysfunction by activating the Nox4/NF-κB pathway. Journal of Hypertension.
  9. Fang H, Deng M, Zhang L, Lu A, Su J, Xu C, Zhou L, Wang L, Ou J, Wang w, Yang T. (2018). Role of (pro)renin receptor in albumin overload-induced nephropathy in rats. Am J Physiol Renal Physiol. (IF=3.38)
  10. Su J, Liu X, Xu C, Lu X, Wang F, Fang H, Lu A, Qiu Q, Li C, Yang T. (2017). NF-κB- Dependent Upregulation of (Pro)Renin Receptor Mediates High NaCl- Induced Apoptosis in Mouse Inner Medullary Collecting Duct Cells. Am J Physiol Cell Physiol. (IF=4.25)
  11. Lu X*, Wang F*, Xu C, Soodvilai S, Peng K, Su J, Zhao L, Yang KT, Feng Y, Zhou SF, Gustafsson JÅ, Yang T. (2016). Soluble (pro)renin receptor via β- catenin enhances urine concentration capability as a target of liver X receptor. Proc Natl Acad Sci. (IF=11.205)
  12. Wang F*, Lu X*, Peng K, Fang H, Zhou L, Su J, Nau A, Yang KT, Ichihara A, Lu A, Zhou SF, Yang T. (2016). Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4. J Am Soc Nephrol. (IF=10.121)