Associate Professor of Pharmacology & Cancer Biology
Associate Professor in Psychiatry and Behavioral Sciences
Member of the Duke Cancer Institute
The focus of the Molecular Pharmacology Laboratory is to understand the role of G protein-coupled receptors in human diseases. Our current focus is to examine the role of the Neurokinin-1/substance P receptor and its interactions with receptor tyrosine kinases in glioblastoma multiforme (GBM). The goal of these translational studies is to develop an effective therapy to halt the growth of GBM. An ongoing side project, which is being conducted in collaboration with several clinicians, is to understand the molecular basis of postoperative delirium.
For additional information on Dr. Kwatra’s lab, please visit https://sites.duke.edu/glioblastoma/
Gustavo Chagoya, MD
Neurosurgery resident at the University of Alabama at Birmingham
Senior Researcher and Lab Manager
Glenn Lesser, MD
Professor of Hematology and Oncology at the Wake Forest School of Medicine
Shawn Kwatra, MD
Assistant Professor of Dermatology at the Johns Hopkins University School of Medicine
President and founder of the Musella Foundation For Brain Tumor Research & Information, Inc
In the News
- Brown KB, Chagoya G., Kwatra SG, Yen T, Keir ST, Hoadley KA, Charles M. Perou, Ahmed Rasheed, Francis Ali-Osman, John H. Sampson, Darell D. Bigner, Madan M. Kwatra (2014). Patient-derived xenografts maintain the proteomic profile of human glioblastoma: Implications for personalized drug development. Journal of Neurochemistry.
- Brown et al. (2013) Subtype-specific expression of the truncated neurokinin-1 receptor in glioblastoma multiforme. Neuro-oncology 15: abstract # CB-009.
- Brown et al.(2012) Neurokinin-1 Receptor: A potential target to inhibit pediatric glioblastoma. Neuro-oncology 14: abstract # CB-51.
- Kwatra M, et al. (2011) Truncated Neurokinin-1 Receptor: Expression in Primary Glioblastoma and Realtionship with Patient Survival. Neuro-oncology 13: abstract # OM-28.
- Akazawa T, Kwatra SG, Goldsmith LE, Richardson MD, Cox EA, et al. (2009) A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas. J Neurochem 109: 1079-1086.