Overview
This mini-symposium will present evidence for the growing role of neuroimmune dysfunction in brain health and disease. Speakers will address how various risk factors, including aging, neurodegeneration, and other vulnerabilities, contribute to neurologic outcomes, including perioperative recovery.
Target Audience
Researchers, physicians, physician-scientists, trainees, and staff.
Learning Objectives
At the conclusion of this activity, participants should be able to:
- Explain the contributions of surgery and hospitalization to cognitive outcomes and brain health
- Discuss evidence on how the immune system impacts brain function
- Present emerging biomarkers from preclinical and clinical studies in delirium and perioperative neurocognitive disorders
| Time | Presenters and Titles |
|---|---|
| 1:30 pm | Niccolò Terrando, BSc, DIC, PhD Welcoming Remarks |
| 1:30−2:00 pm | Staci D. Bilbo, PhD Lung-Brain Communication in Neurological Outcomes |
| 2:00−2:30 pm | Ashley Moseman, PhD Nose to Brain Connections: Implications for Health and Disease |
| 2:30−3:00 pm | Michael J. Devinney Jr., MD, PhD Unbiased Proteomics of Pre- and 24-Hour Postoperative Cerebrospinal Fluid Reveals Novel Protein Markers of Postoperative Delirium |
| 3:00−3:30 pm | Leah Acker, MD, PhD The Aging Brain-Heart-Immune Axis, Inflammatory Resolution, and Postoperative Delirium |
| 3:30−3:45 pm | Q&A |
| 3:45−4:00 pm | Coffee Break |
| 4:00−5:00 pm | Mervyn Maze, MB, CHB KEYNOTE LECTURE: IL-6 Trans-Signaling – A Shared Pathway for Immune-Mediated Inflammatory Diseases (IMIDs) Including Perioperative Neurocognitive Disorders |
| 5:00−5:30 pm | Roundtable Discussion |
Keynote Speaker
Mervyn Maze, MB, CHB
Professor
Department of Anesthesia and Perioperative Care
University of California
San Francisco
Dr. Mervyn Maze is Professor of Anesthesiology and Perioperative Care at the University of California, San Francisco, where he served as department chair from 2009 to 2015. Dr. Maze received his Bachelor of Medicine and Bachelor of Surgery from the University of Cape Town, South Africa. He spent several years in London, United Kingdom, as a Registrar at the Royal Free Hospital before joining Stanford University for about 20 years. He returned to London in 1999 as the Sir Ivan Magill Professor of Anaesthetics at Imperial College and Honorary Consultant in Anaesthesia at the Chelsea and Westminster Hospital, until 2009.
Dr. Maze has authored over 200 scientific articles, edited three medical textbooks, and received 16 patents for his research discoveries. He pioneered studies on general anesthetics, notably co-inventing dexmedetomidine, widely used for sedation in perioperative and critical care, noble gases such as Xenon as a novel organ protectant, and perioperative neurocognitive outcomes following anesthesia and surgery. His innovative research earned him several awards, including the American Society of Anesthesiology's Excellence in Research award in 2003 and the Lifetime Achievement Award from the International Society of Anaesthetic Pharmacology in 2024.
Leah Acker, MD, PhD
Assistant Professor of Anesthesiology
Duke University
Staci D. Bilbo, PhD
Professor of Psychology and Neuroscience
Duke University
Michael J. Devinney, MD, PhD
Assistant Professor of Anesthesiology
Duke University
Ashley Moseman, PhD
Assistant Professor of Integrative Immunobiology
Duke University
Please register by May 26th
Venue
The Mary Duke Biddle Trent Semans Center for Health Education is the main educational facility for the Doctor of Medicine (M.D.) program. The six-story, 104,000-square-foot health education building opened to students in 2013 and features a floor dedicated to simulation laboratories that can transform from mock clinical exam rooms to surgery suites and emergency rooms.
Medical education administrative offices are located on 8 Searle Center Drive, Durham, NC 27710, behind the Bryan Research building and next to the Medical Center Library & Archives.
Parking
The Trent Semans Center does not have dedicated parking. Users of the facility may be dropped off at the west entrance of the building on Searle Center Drive, with handicap accessibility at this entrance.
The following parking garages may be utilized for visitors attending events at TSCHE:
Parking Garage I: Trent Drive across from Duke Clinic and Duke Medicine Pavilion
Parking Garage II: Erwin Road access from Duke University Hospital
Parking Garage IX (Eye Center): Research Drive Garage: Research Drive and Erwin Road
Visitors are responsible for all parking expenses assessed at the prevailing rate. The Trent Semans Center does not reimburse for any parking expenses. Please be advised any vehicle parked outside the Trent Semans Center is considered parked illegally and will be subject to ticketing and/or towing at the expense of the owner. Additional information on parking services may be found online: https://parking.duke.edu/visitor-parking/.