Dr. Moon Awarded $2M for Diving Studies

Richard E. Moon, MD, CM, MSc, FRCP, FACP, FCCPDuke Anesthesiology’s Richard Moon, MD, CM, MSc, FRCP(C), FACP, FCCP, has been awarded more than $2 million in funding for diving studies from branches of the United States Navy.

The Office of Naval Research has awarded Moon a three-year, $1,209,589 grant for his project, “Integrated Diaphragmatic Function, Chemosensitivity, Erythrocyte Gas Transport and Endurance in Exercising Divers.”

Moon’s study will determine (1) the effectiveness of breathing carbon monoxide on diaphragm training (his research team has previously shown that low dose carbon monoxide upregulates mitochondrial biogenesis in humans); (2) whether carbon monoxide-enhanced diaphragm training increases endurance in divers during underwater exercise; (3) the degree to which oxygen and carbon dioxide exchange is determined by gas channels in human red blood cells.

Additionally, the Naval Sea Systems Command (NAVSEA) has awarded Moon, medical director of Duke’s Center for Hyperbaric Medicine & Environmental Physiology, an $850,502 contract for his project, “Perfluoromethane to Reduce Decompression Sickness after Heliox Dives.” This contract will fund studies in pigs to determine whether perfluoromethane breathing during decompression from a dive reduces decompression sickness.

Stacey HiltonDr. Moon Awarded $2M for Diving Studies
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Dr. Gasier Awarded Naval Research Grant

Heath Gasier, PhDThe Office of Naval Research has awarded Duke Anesthesiology’s Heath Gasier, PhD, a $227,954 grant to study the effects of hyperbaric oxygen on skeletal muscle calcium regulation and mitochondrial function.

Oxidant production increases with strenuous muscle contractions and has been reported to cause or contribute to fatigue. It is, therefore, probable that intramuscular oxidant production is increased during prolonged and repeated HBO2 exposures and results in damage to organelles and regulatory proteins involved in muscle contraction and bioenergetics.

This research will help Gasier determine the impact of skeletal muscle oxidant production on calcium regulation and mitochondrial function in mice exposed to HBO2, ultimately identifying new approaches for preventing oxygen toxicity and optimizing performance in divers.

In this study, he will implement an innovative combination of biological techniques. His approach allows for real time measurement of total and mitochondrial superoxide and calcium levels, and mitochondrial membrane potential in live muscle fibers ex vivo. Combined with immunoblotting and immunofluorescence, he aims to identify the potential source of muscle fatigue. Gasier’s central hypothesis is that prolonged and repeated HBO2 exposures increase oxidation of RyR1 and STIM1 that increases intracellular and mitochondrial calcium uptake, resulting in impaired mitochondrial function. This hypothesis is based on the synthesis of work by others.

Gasier’s work is expected to discover whether critical targets involved in muscle contraction are influenced by HBO2. Results of this research will have an important and positive impact because they will offer a strong scientific framework for testing specific drugs or antioxidants on muscle and aerobic exercise performance after HBO2.

Stacey HiltonDr. Gasier Awarded Naval Research Grant
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Dr. Moon Named Diver of the Year

Richard E. Moon, MD, CM, MSc, FRCP, FACP, FCCPThe Divers Alert Network (DAN) has named Duke Anesthesiology’s Richard Moon, MD, CM, MSc, FRCP(C), FACP, FCCP, the 2021 DAN Rolex Diver of the Year.

Moon is the medical director of the Duke Center for Hyperbaric Medicine and Environmental Physiology and a former medical director of DAN. Throughout his more than 40-year career in dive medicine and research, Moon has worked to gain a better understanding of how the human body functions at environmental extremes. His research focuses on gas exchange and cardiorespiratory function in the body while deep underwater or at high altitude.

Moon earned his doctor of medicine at McGill University in Montreal and completed residency and fellowship training at the University of Toronto and Duke University. He began working at the Duke hyperbaric center in 1979. Throughout his career, Moon has investigated numerous phenomena that affect divers, including immersion pulmonary edema, arterial gas embolism, hypoxia, and decompression sickness. He has also worked to improve the decompression procedures used in altitude diving and has studied the utility of novel breathing gases in decompression. In addition to being a prolific researcher, Moon teaches and practices medicine. He has won multiple awards for teaching and mentoring medical students. And not only has he enhanced the understanding of diving and treatment of injured divers, he has provided hyperbaric oxygen therapy and other medical care, advice, and assistance directly to hundreds of divers who were suffering from diving-related injuries.

Moon’s support for explorers and adventurers goes beyond treating injured people and establishing safety standards and procedures; he also works with divers and climbers prior to travel to help them determine their fitness for diving or ascending to altitude. Beyond working with divers and travelers, Moon also directs care for people with various medical conditions who can benefit from hyperbaric oxygen therapy. These conditions include carbon monoxide poisoning, wounds that aren’t healing properly, radiation-induced tissue injuries and more.

Moon’s work on the effects of submersion and decompression has benefited countless divers over the years. Through his commitment and significant contributions to dive medicine, Moon has made diving safer for all.

“One of our major tasks as senior people in any field is to help the next generation, and I really love doing that,” says Moon. “If the Rolex award provides more opportunities to do that I’ll be absolutely ecstatic.”

Source: Our World-Underwater Scholarship Society awards program announcement (June 2021)

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Class of 2021 Graduates from Duke Anesthesiology Training Programs

Class of 2020 Virtually Graduates from Duke Anesthesiology Training Programs

Duke Anesthesiology’s residency and fellowship classes of 2021 gathered on June 5 and 6 to celebrate their graduation from the department’s training programs. Thirteen residents received their diplomas at the ceremony held at The Pavilion at the Angus Barn and 35 fellows received their diplomas at the ceremony held at The Pit.

Duke Anesthesiology Fellowship Graduates of 2021

The Duke Anesthesiology Fellowship Education Program is led by Dr. Mark Stafford-Smith, who says “I sincerely congratulate all of our fellow graduates who have succeeded despite a host of challenges throughout the past year and have contributed in a significant way to Duke Anesthesiology’s response to Covid 19.”

Duke Anesthesiology Resident Graduates of 2021

The Duke Anesthesiology Residency Program is led by Dr. Annemarie Thompson, with assistant residency program directors, Drs. Brian Colin and Ankeet Udani. “I’m so proud of our residents, not only for the excellent physicians they have become, but also for the resilient and kind people they are for having endured a residency experience like no other,” says Thompson. “I am honored to have had the opportunity to get to know each and every one of the graduates, and I look forward to watching them make a difference in their patients’ lives and our global community.”

Resident leadership positions were also recognized during the ceremony:

Chief Residents: Drs. Megan Fah and Harold Douglas Wackerle
Education Chiefs: Drs. Michael Cutrone and Russell-John Krom
ACES Chief: Dr. Leah Acker

Congratulations to all of the graduates!

Michael Cutrone, DO

Michael Cutrone, DO

James Dierkes, MD

James Dierkes, MD

Megan Fah, MD

Megan Fah, MD

Russell-John Krom, MD

Russell-John Krom, MD

Gabrielle Madsen, MD

Gabrielle Madsen, MD

Manal Mirreh, MD

Manal Mirreh, MD
University of Michigan - Pediatric Anesthesiology Fellowship

Sean Moore, MD

Sean Moore, MD

Derek Nelsen, MD

Derek Nelsen, MD

Jason Stearns, MD

Jason Stearns, MD

Rose Tang, MD

Rose Tang, MD

Bella Vishnevsky, MD

Bella Vishnevsky, MD

Harold Wackerle, MD

Harold Wackerle, MD

Allesyn Young, MD

Allesyn Young, MD
Children’s National Hospital – Pediatric Anesthesiology Fellowship

Adult Cardiothoracic Anesthesiology

Jon Andrews, MD
David Carroll, DO

David Carroll, DO
Future location: Charleston, SC

Andre Gosling, MD

Andre Gosling, MD
Future location: Birmingham, AL

Lauriane Guichard, MD

Lauriane Guichard, MD
Future location: Chapel Hill, NC

Michael Gysel, MD

Michael Gysel, MD

Joseph Kamassai, MD

Joseph Kamassai, MD
Future location: Baltimore, MD

Robert Morris, MD

Robert Morris, MD
Future location: Albany, NY

Justice Mushonga, MB ChB

Justice Mushonga, MB ChB
Future location: Largo, FL

Sawyer Naze, MD

Sawyer Naze, MD
Future location: Chicago, IL

Tarek Radwan, DO

Tarek Radwan, DO
Future location: Raleigh, NC

Estuardo Saravia Fernandez, MD

Estuardo Saravia Fernandez, MD

Robin Schiller, MD, DMD

Robin Schiller, MD, DMD
Future location: Boston, MA

Alexander Stoker, MD

Alexander Stoker, MD
Future location: Phoenix, AZ

Danielle Van Patten, MD

Danielle Van Patten, MD
Future location: Morristown, NJ

Critical Care Medicine

Jonathan Curley, MD

Jonathan Curley, MD
Future location: Jonathan Curley, MD

Selby Johnson, MD

Selby Johnson, MD

Daryl Kerr, MD

Daryl Kerr, MD

Karl Kristiansen, MD

Karl Kristiansen, MD

Michelle McGauvran, MD

Michelle McGauvran, MD
Future location: Colorado Springs, CO

Sachin Mehta, MD

Sachin Mehta, MD

Osamudiamen Obanor, MD

Osamudiamen Obanor, MD
Future location: Houston, TX

Karuna Puttur Rajkumar, MBBS

Karuna Puttur Rajkumar, MBBS

Obstetric Anesthesiology

Olga Diomede, MD

Olga Diomede, MD
Future location: Portland, ME

Riley Landreth, DO

Riley Landreth, DO
Future location: San Diego, CA

Pain Medicine

Adam Kemp, MD

Adam Kemp, MD
Future location: Eugene, OR

Eric Ngo, MD

Eric Ngo, MD
Future location: Hawaii

Anuj Shah, MD

Anuj Shah, MD
Future location: Greensboro, NC

Bharat Sharma, MD

Bharat Sharma, MD
Future location: TBD

Pediatric Anesthesiology

Alison Brown, MD

Alison Brown, MD
Future location: Charlotte, NC

John McManigle, MD, DPhil

Regional Anesthesiology and Acute Pain Medicine

Stephan Frangakis, MD, PhD
Charles Horres, MD

Charles Horres, MD
Future location: Chicago, IL

Brian Nevitt, MD

Brian Nevitt, MD
Future location: Santa Cruz, CA

Andrew Wong, MD

Undersea and Hyperbaric Medicine

Christopher Winstead-Derlega, MD

Christopher Winstead-Derlega, MD
Future location: Nag’s Head, NC

Stacey HiltonClass of 2021 Graduates from Duke Anesthesiology Training Programs
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Duke Anesthesiology Celebrates 29 Years of Scientific Excellence

29th Annual Academic Evening

William Maixner, DDS, PhD

William Maixner, DDS, PhD

Despite the novel coronavirus pandemic, 84 poster abstracts – ranging from basic science, clinical trials and case reports – were submitted and showcased at Duke Anesthesiology’s 29th Annual Academic Evening, an event that aims to advance anesthesia, critical care and pain management. It once again took place virtually on May 11 with at least 115 departmental members in attendance, eager to celebrate scholarly activity and scientific excellence from its junior-level investigators and faculty; leadership also honored the life and legacy of the late Dr. William “Bill” Maixner, who served as the department’s vice chair for research for three years and co-chair of the event.

Jeffrey C. Gadsden, MD, FRCP, FANZCA

Jeffrey C. Gadsden, MD, FRCP, FANZCA

“We were thrilled to see the depth and breadth of engagement in this year’s Academic Evening,” says Dr. Jeffrey Gadsden, event chair and associate professor of anesthesiology. “In a year when clinical research was interrupted by the pandemic, we saw an exceptional number of abstract submissions, which shows not only the commitment to scholarly discovery here at Duke Anesthesiology, but the resilience of our trainees and their faculty mentors.”

One of the anticipated highlights of the annual event is the presentation of the Bill White Award for resident research. White was involved in the design, data control and examination, and statistical analysis of biomedical studies in both observational and clinical trials within Duke Anesthesiology for more than 20 years. Dr. Leah Acker, Academic Career Enrichment Scholars (ACES) chief resident, received first place in this category for her project, titled “Perioperative EEG Complexity Measures as Predictors of Postoperative Delirium in Older Adults.”

Leah Acker, MD

Leah Acker, MD

“Academic Evening has been one of my favorite events since I first attended as a Duke medical student, and I’m honored to receive the Bill White research award this year. It’s humbling to think of all the seminal trials and research that he was a part of in this department, and to feel that in some small way, my work is helping to carry that tradition of excellence forward,” says Acker. “I am grateful for the opportunity to apply my engineering background and skills to the clinical problems we see as anesthesiologists. None of my work would be possible without the superb mentorship I’ve received from Drs. Miles Berger, Heather Whitson, and Marty Woldorff, the statistical guidance from Mary Cooter Wright, and our department’s on-going dedication to resident education.”

Guest judge, Dr. Deborah J. Culley, chair of the Department of Anesthesiology and Critical Care at the University of Pennsylvania Perelman School of Medicine, was particularly impressed with the number of posters submitted by residents, saying “this past year has been a period of unprecedented pressure” and acknowledging the essential role of residents during covid surges. “Hats off to you all for being able to accomplish such amazing research during that period of time. Research from this event suggests that there is a bright future in anesthesiology, and you really are that future.”

Deborah J. Culley, MD

Guest judge, Dr. Deborah J. Culley

Culley went on to speak about the importance of academics being maintained within the anesthesiology specialty, applauded the department for its commitment to research, and left the audience with a message about resilience: “When things don’t go the way you want them to go, you have to be resilient enough to look at what the reviewers are saying to you…part of becoming an academician is recognizing that you can’t always come out on top. But if you persevere and keep going through the process, you’ll find yourself in the exact position that each of you are here today. I think the individuals coming from your institution are going to be the leaders of the future.”

“Dr. Culley was a wonderful guest judge,” adds Gadsden. “She provided the presenters with inspiring words of wisdom about the importance of doggedness in an academic career, despite the obstacles and setbacks that are frequently encountered.”

Congratulations to each of the award winners listed below.

2021 Academic Evening Award Winners:

Post Doc Basic Science

1st Place: Sharat Chandra: “New Non-Sulfonamide Inhibitors of Voltage-Gated Sodium Channel 1.7 for Treatment of Pain and Itch”

2nd Place: Su Hyoun Park: “Altered Resting State Activity of the Brain Reward Circuit in Fibromyalgia”

3rd Place: Satya Achanta: “TRPV4 Inhibitor Counteracts Phosgene-Induced Pulmonary Inflammation and Edema”

Fellow Clinical Research (Dick Smith Award)

1st Place: Riley Ann Landreth: “The ED90 of Intrathecal Chloroprocaine for Cervical Cerclage Placement: An Up-Down Sequential Allocation Dose-Response Study”

2nd Place: Olga Diomede: “A Randomized Controlled Trial of Dural Puncture Epidural versus Standard Labor Epidural Technique in Parturients with Obesity”

3rd Place: Michelle McGauvran: “Association Between Gabapentinoids and Postoperative Pulmonary Complications in Patients Undergoing Thoracic Surgery”

Resident Research (Bill White Award)

1st Place: Leah Acker: “Perioperative EEG Complexity Measures as Predictors of Postoperative Delirium in Older Adults”

2nd Place: Katherine W. Sun: “Comparison of Neuraxial Techniques for Labor Analgesia: A Retrospective Analysis”

Medical Student Research

1st Place: Tim Beck: “Altitude Decompression Corrections for 35% Oxygen Diving at 10,000 and 12,000 ft Elevation”

2nd Place: Sierra Camille Mims: “Intrathecal Bupivacaine versus Chloroprocaine for Transvaginal Cervical Cerclage: A Retrospective Analysis”

CRNA/DNP/Grad/Undergrad Research

1st Place: Erica Harris: “Sensory Evoked Potential Stimulation Interferes with TOF Assessment and Increases Risk for Undiagnosed Residual Neuromuscular Blockade”

Case Report

1st Place: Robert Morris: “False Positive Intraoperative Diagnosis Of Severe Aortic Insufficiency Associated With An A-V Dialysis Fistula”

Quality Improvement

1st Place: James Dierkes: “A Picture Says a Thousand Words: Use of a Visual Aid to Improve Patient Positioning During Neuraxial Procedures”

Stacey HiltonDuke Anesthesiology Celebrates 29 Years of Scientific Excellence
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