Release of our 2014 BluePrint Publication

Dear Duke Anesthesiology Alumni and Friends,

I am pleased to announce the release of our 2014 issue of BluePrint. Like last year’s publication, you will be able to read about the incredible work and progress being made in the department through the BluePrint News & Updates website as well as on your smart phone or tablet.

Chris KeithRelease of our 2014 BluePrint Publication
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2014 Final DIG Report: Zhiquan Zhang, PhD

Sirtuin-3 Modulation of Acetylation in the Treatment of Perioperative Myocardial Reperfusion Injury

Heart cells deficient in SIRT3 by introducing siRNA (figure 1: Western Blot) showed increased necrosis (figure 2: ELISA) and apoptosis (figure 3: ELISA), which was partially rescued by ANXA1sp. (Ctrl, control; scrR, scrambled RNA; siR, siRNA; SP, ANXA1sp. Data were presented as mean +/- SD, n=3. *P<0.05 and #P<0.01.)

Heart cells deficient in SIRT3 by introducing siRNA (figure 1: Western Blot) showed increased necrosis (figure 2: ELISA) and apoptosis (figure 3: ELISA), which was partially rescued by ANXA1sp. (Ctrl, control; scrR, scrambled RNA; siR, siRNA; SP, ANXA1sp. Data were presented as mean +/- SD, n=3. *P<0.05 and #P<0.01.)

Zhiquang Zhang, PhDThe overall goal of this study is to determine how to manipulate Sirtuin-3 (SIRT3), a longevity factor in mammals, to protect the heart from perioperative myocardial injury (PMI).

Chris Keith2014 Final DIG Report: Zhiquan Zhang, PhD
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2014 DIG Report: Thomas Van de Ven, MD, PhD

The role of FXR, TGR5 and the Bile Acid Pathway in the Prevention and Treatment of Chronic Post-Nerve Injury Pain

Figure 1: Treatment with the TGR5 agonists deoxycholate (DCA) and oleanolic acid (OA) prevents pro-inflammatory chemokine (MCP-1) release in cultured astrocytes

Figure 1: Treatment with the TGR5 agonists deoxycholate (DCA) and oleanolic acid (OA) prevents pro-inflammatory chemokine (MCP-1) release in cultured astrocytes

Thanks to the generous support of the Duke Anesthesiology DREAM Campaign, we have made significant progress toward our goal of understanding a previously unknown molecular pathway – the TGR5 – that regulates the unwanted transition from acute to chronic neuropathic pain after surgery.

Chris Keith2014 DIG Report: Thomas Van de Ven, MD, PhD
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2014 DIG Report: Miles Berger, MD, PhD

Determination of the Role of Alzheimer’s Disease Pathways in Post-Operative Cognitive Dysfunction

Over the past year, we have enrolled 48 patients in the ACTIVATE (Alzheimer’s Disease Markers and Cognitive Testing after Inhaled vs. IntraVenous Anesthetic Treatment in the Elderly) study.

Chris Keith2014 DIG Report: Miles Berger, MD, PhD
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2013 Final DIG Report: Karthik Raghunathan, MD, MPH

Comparative Effectiveness in Perioperative and Critical Care Medicine: Crystalloid Fluid Therapy

Figure 1: Receipt of balanced fluids versus in-hospital mortality

Figure 1: Receipt of balanced fluids versus in-hospital mortality

Intravenous electrolyte fluids (crystalloid solutions) are routinely used to resuscitate seriously ill patients that have actual or perceived signs of inadequate circulation.

Chris Keith2013 Final DIG Report: Karthik Raghunathan, MD, MPH
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2013 Final DIG Report: Steve Melton, MD

Neurointerventional Regional Anesthesia to Improve Hand Rehabilitation in Stroke

Over the course of this year, collaboration between investigators from anesthesiology, physical therapy, neurology, and the Brain Imaging and Analysis Center has provided the detailed groundwork, preparation, and coordination necessary to facilitate successful recruitment, enrollment, and implementation for this study.

Chris Keith2013 Final DIG Report: Steve Melton, MD
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