Dr. Wischmeyer Awarded Perioperative Education Grants

Paul E. Wischmeyer, MD, EDICDuke Anesthesiology’s Paul Wischmeyer, MD, EDIC, has been awarded three grants totaling $179,772 for the following educational projects:

  1. “Nutrition in ERAS: What You Must Know” (education podcasts in perioperative nutrition)
    Funding Agency: Abbott Nutrition
    Grant Amount: $100,000 (DCRI)

This project is part of the Duke Clinical Research Institute (DCRI) Evidence to Practice Series, a multi-format educational program aimed at translating the latest research findings into clinical context through case driven discussions. In early 2018, DCRI will launch “Nutrition in ERAS: What You Must Know” as the latest topic in the Evidence to Practice Series line-up. The program will be directed by Dr. Paul Wischmeyer and will include six audio podcasts and a satellite symposium at Digestive Disease Week 2018.

  1. “Improving Physician and Provider Education on Perioperative and Hospital Malnutrition”
    Funding Agency: Abbott Nutrition
    Grant Amount: $50,000 (Duke Anesthesiology)

The overall goal of this project is to conduct an exploratory clinical trial to address the following questions: 1) what is the effect of a prebiotic (Nutriflora scFOS via Vital AF) containing enteral flora on longitudinal gut, oral and skin microbiome in critically ill neurological injury trauma patients and 2) does an alteration in microbiome correlate with a signal of changed clinical outcomes such as GI acquired infections (like Clostridium Difficile and antibiotic associated-diarrhea) and ventilator associated pneumonia? This proposal will link Dr. Wischmeyer’s long-standing interest in enteral nutrition delivery to improve outcome and nutrition critical care trial expertise using novel methodology via microbial community profiling with high-throughout sequencing of the 16S rRNA gene. This initial trial will establish the feasibility of conducting larger scale trials and collect the first data on the role of prebiotic fiber (Nutriflora scFOS) on microbiome profiling. It may allow for identification of patients who will benefit from prebiotic formulas and provide an objective method to drive the use of prebiotic containing formulas like Vital AF.

  1. “Improving Provider Education on Optimal Use and Placement of New IRIS Camera Guided Feeding Tube”
    Funding Agency: Cardinal Health
    Grant Amount: $29,772 (DCRI)

The goal of this project is to create provider educational materials and videos to instruct clinicians in the use of new camera-guided enteral feeding tube placement technology to increase patient safety and delivery of nutrition.

Chris KeithDr. Wischmeyer Awarded Perioperative Education Grants
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Dr. Davison Awarded ASPEN Grant to Improve Critical Care Outcomes

James Davison, PhD

James Davison, PhD

The American Society of Parenteral and Enteral Nutrition (ASPEN) Rhoads Research Foundation has awarded Duke Anesthesiology’s James Davison, PhD, a lab research analyst and director of The Wischmeyer Lab, a $25,000 grant (with potential second-year funding of an additional $25,000) for his project, titled “Modulation of Organ Injury by Faecalibacterium Prausnitzii in Critical Illness.” Dr. Davison’s long-term research objective is to establish nutritional and probiotic therapies that support organ function and improve outcomes in critical care patients.

According to the project’s abstract, intensive care unit (ICU) admission is associated with a loss of “health promoting” bacteria and a rapid dysbiosis of the intestinal microbiota. Specifically, a recent multi-center ICU microbiome clinical trial from The Wischmeyer and Knight (UC San Diego) Labs demonstrated a significant loss of the probiotic microorganism, Faecalibacterium prausnitzii, which generates metabolites and anti-inflammatory peptides that support intestinal function and attenuate local inflammation in experimental colitis models. Based on the clinical findings and the known roles of F. prausnitzii in attenuating local inflammation, Dr. Davison and his project mentor, Dr. Paul Wischmeyer, have developed this central hypothesis: F. prausnitzii and/or its metabolites attenuate systemic inflammation, improve organ function and reduce morbidity/mortality in sepsis. Thus, their two project aims include 1) directly addressing the working hypothesis that oral supplementation of F. prausnitzii protects intestinal and extra-intestinal organ function during sepsis. Using the accepted cecal-ligation and puncture model of sepsis, they will test if F. prausnitzii attenuates systemic inflammation and promotes extra-intestinal organ function. They will also utilize next-generation sequencing to determine if F. prausnitzii mediates metabolic and inflammatory transcriptional responses of organs in septic mice, and 2) directly addressing the working hypothesis that peptides and metabolites derived from F. prausnitzii suppress systemic inflammation. Using protein and metabolite mass spectrometry, they will test for enrichment of serum metabolites and peptides that are only present in mice that receive F. prausnitzii. They will synthesize peptides that are unique in the serum of mice that receive F. prausnitzii and will test if oral gavage or tail-vain injection of these synthesized peptides have the capacity to reduce inflammation in septic mice.

Drs. Davison and Wischmeyer believe that this project addresses a significant obstacle that prevents wider use of probiotic therapies (and other nutritional therapies) in critical illness – and that the lack of understanding of the molecular mechanisms mediate probiotic contributions to human health. They predict that their translational research plan will support their long-term research objectives in identifying novel mechanisms that mediate probiotic organ protection in illness, leading to new therapies to prevent and treat sepsis and critical illness.

Chris KeithDr. Davison Awarded ASPEN Grant to Improve Critical Care Outcomes
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Dr. Swaminathan Appointed Vice Chair Position

We are pleased to announce that Madhav Swaminathan, MD, FASE, FAHA, has been appointed as the vice chair for faculty development at Duke Anesthesiology, effective January 1, 2018. In his new role, Dr. Swaminathan will be responsible for nurturing our faculty with the vision, mentorship, opportunities and infrastructure they need to be leaders in “changing the face of anesthesiology.”

“It is an honor and privilege to serve the department in any capacity. This particular position is important as it helps faculty at all levels achieve their professional goals while advancing the mission of the department,” says Dr. Swaminathan.

Dr. Swaminathan’s short-term goals are to 1) develop robust methods to assess faculty needs, 2) make institutional resources for developing professional skills, such as writing, public speaking and collaborative research opportunities, readily available to departmental faculty, 3) streamline mentorship pathways for mentees and mentors, 4) simplify the pathway for navigating the appointments, promotions and tenure process, and 5) establish new programs for wellness, inclusion, leadership and skills development.

Dr. Swaminathan, professor of anesthesiology, arrived at Duke in 2000 as a cardiothoracic anesthesiology fellow. Two years later, he joined the department as faculty and developed his research interests in kidney outcomes after cardiac surgery. In 2004, he assumed a leadership role as the director of perioperative echocardiography at Duke. And in 2013, he was appointed as clinical director of cardiothoracic anesthesiology. During his time at Duke, Dr. Swaminathan has notably earned two historic appointments. In 2015, he was named the 16th Feigenbaum Lecturer at the scientific sessions of the American Society of Echocardiography (ASE), marking the first time a cardiac anesthesiologist was given this honor. This year, he was appointed vice president of the ASE, and in 2019, he is slated to become the first anesthesiologist to hold the position of president in the organization’s 44-year history.

“I am fortunate to have giants in this field as my mentors and have learned and benefited from their commitment to faculty development. During that process, I have successfully mentored junior faculty into leadership roles and have gained a deeper understanding of what makes a faculty member a successful professional in our field,” says Dr. Swaminathan. “I would like all faculty members to not only develop their own careers, but also mentor junior members along the way and ultimately advance the department’s vision. I look forward to working with our faculty to develop innovative methods for enhancing personal and professional growth.”

Please join us in extending congratulations to Dr. Swaminathan on his new position.

Chris KeithDr. Swaminathan Appointed Vice Chair Position
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Dr. Grantham Awarded Duke AHEAD Grant

Ashley Grantham, PhD

Ashley Grantham, PhD

Duke Academy for Health Professions Education and Academic Development (Duke AHEAD) has awarded Duke Anesthesiology’s Ashley Grantham, PhD, and co-investigators a $5,000 research and innovations grant for her project, titled “The development, implementation, and evaluation of a learning community to support education research in the health professions.” This funding is aimed at improving health professions education through innovative approaches to instruction or assessment. Co-principal investigators include Deborah Engle, EdD, MS, and Kyle Covington, PT, DPT, PhD.

According to the project proposal, health professions education (HPE) research has the ability to improve the quality of teaching and learning in the health professions by providing insight into effective strategies, programs and practices. These findings have the ability to impact not only learner outcomes but patient outcomes as well (O’Sullivan & Irby, 2011). However, research in health professions education sometimes lacks the rigor found in traditional education research and clinical and basic science research.

Drs. Grantham, Engle and Covington assert that professional development devoted to HPE education, research and design will help increase participants’ knowledge of solid education research design and methodologies, addressing some of the needs established in the literature on HPE.

The investigators specifically aim to implement an interprofessional development program focused on improving the education research knowledge and skills of health professionals and professional staff working in HPE. They plan to use best practices in evaluation to assess the impact of an HPE research professional development program on 1) increasing participant knowledge of education research concepts and practices and 2) fostering research in HPE. They hypothesize that participation in this program will increase participant knowledge of education research concepts and scholarly productivity in the area of health professions education research.

Chris KeithDr. Grantham Awarded Duke AHEAD Grant
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Fellows Awarded Funding in Duke Competition

Drs. Dinesh Kurian, Kendall Smith, Christina Pedro

Duke Anesthesiology critical care medicine fellows, Drs. Dinesh Kurian and Kendall Smith, and obstetric anesthesiology fellow, Dr. Christina Pedro, along with their faculty support, have received $3,000 in funding for each of their projects submitted to the 2017 Duke Graduate Medical Education High-Value Care Quality Improvement Competition.

Dr. Kurian’s Project: “Appropriate Selection of Vasopressor Infusion in the Cardiothoracic ORs to Reduce Cost.” Faculty support: Dr. Cory Maxwell (Cardiothoracic Anesthesia)

Dr. Pedro’s Project: “Postoperative Opioid Use and Practices.” Faculty support: Dr. Ashraf Habib (chief, Women’s Anesthesia)

Dr. Smith’s Project: “Reducing Delirium via Non-pharmacologic Methods in the Surgical Intensive Care Unit.” Faculty support: Drs. Madan Kwatra (Basic Sciences) and Nazish Hashmi (Cardiothoracic Anesthesia)

Dr. Paul Wischmeyer is also recognized as faculty support for Duke Neurology’s Dr. Joshua VanDerWerf’s winning project, titled “Improving nutrition delivery in our critically ill.” This funding is made possible by a grant from The Duke Endowment to support Duke house staff in high-value care learning and practice.

Chris KeithFellows Awarded Funding in Duke Competition
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That’s a Wrap! Highlights from ASA 2017

That’s a Wrap! Highlights from ASA 2017We would like to thank all members of our department who helped make this year’s American Society of Anesthesiologists (ASA) meeting in Boston a huge success! Duke Anesthesiology made a big impression at this year’s event with 51 faculty and trainees participating in the conference, including 84 lectures, workshops, panel discussions, presentations, and more. Please join us in congratulating our team of authors who received the 2017 Anesthesia Patient Safety Foundation Resident Quality Improvement Recognition Award at the ASA for their video, titled “A Bedside Tool to Improve Safety and Efficiency of Cardiothoracic ICU Patient Transport: The Duke ICU Transition to OR (DITTO) Checklist.” Authors include: Suraj Yalamuri, MD, and Michael Plakke, MD (team leaders); John Haney, MD, AB, MPH; Brad Taicher, DO, MBA; Madhav Swaminathan, MD, FASE, FAHA; Cory Maxwell, MD (mentors); Hassan Amhaz, MD; Vinca Chow, MD; Heather Pena; Joseph Deblasio; Mollie Kettle; Jhaymie Cappiello; Jessica Lumbard; Rachel Gambino; Courtney Thurman.

During the conference, we hosted Duke Anesthesiology’s 29th Annual ASA Alumni Event at The Roof at Taj Boston. Nearly 200 guests (including departmental faculty, trainees, staff, alumni, donors and friends) joined us atop the 17th floor of Boston’s most iconic hotel, surrounded by panoramic views of the city’s Back Bay and skyline for a night of live jazz music, culinary cuisine and celebration. Guests enhanced their evening by bidding on 13 silent auction items (graciously donated by the department, faculty and staff) to benefit our Global Health Program. This year’s winning bidders raised nearly $2,500 which will help fund our residents’ travel expenses for their global health missions.

Two of the most anticipated highlights of the evening were: 1) the announcement of the Mark F. Newman Professorship in which we shared this inspirational video. Donors who generously endow this new professorship are not only ensuring the progress of medicine, research and academic excellence, they are giving a gift for future generations to come. Please consider donating to preserve Dr. Newman’s legacy. 2) the reveal of the 2018 DREAM Innovation Grant (DIG) recipients.

Qing Ma, MD

“The Role of Sirtuin-3 in Neuroinflammation and Perioperative Cerebral Injury”

Jamie Privratsky, MD, PhD

“The Role of Dendritic Cells in Acute Kidney Injury and Renal Healing”

DIGs are part of the Duke DREAM Campaign which was launched in 2007. These grants support innovative high-risk and potentially high-reward investigations to accelerate anesthesia and pain management research. Each DIG recipient can receive up to $30,000 in seed money for their pilot study which ultimately helps them apply for and obtain extramural funding. To date, $662,900 has been funded by DIGs which has led to nearly $8 million in extramural funding. We would like to express our appreciation to the DIG Application Review Committee and the donors who continue to support our research programs and initiatives, ultimately helping us transform the future of patient care.

It was also another successful fundraiser at the 8th Annual ASA Sponsored Run For The Warriors 5k race, dedicated to the men and women wounded during service, their families and families of the fallen. We’re proud to announce that for the seventh year in a row, the Duke Anesthesiology team won first place for fundraisinga total of $11,895! All proceeds from the race benefit wounded warriors and their families through the many Hope For The Warriors® programs. Thank you to the 42 race participants and donors who raised money for this nonprofit veteran service organization. A special congratulations goes to Dr. Atilio Barbeito (faculty), his son, Jose, and Dr. Stephanie Jones (fellow) who medaled for having one of the top three race times in their division (gender/age group). Dr. Barbeito placed 2nd in his division and 7th overall. Jose placed 2nd in his division and 5th overall. Dr. Jones placed 3rd in her division.

We sincerely appreciate your continued support of Duke Anesthesiology and your commitment to our mission of providing extraordinary care through a unique culture of innovation, education, research and professional growth. We are particularly grateful to those who worked in the operating rooms during the ASA so that others on our team could attend. Here’s to a successful 2018 and we look forward to celebrating at our ASA alumni event next October in San Francisco!

Chris KeithThat’s a Wrap! Highlights from ASA 2017
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