Dr. Privratsky Receives Clinical Investigator Award

Jamie Privratsky, MD, PhDThe National Institutes of Health’s National Institute of General Medical Sciences has awarded Duke Anesthesiology’s Jamie Privratsky, MD, PhD, a 5-year, $939,324 K08 grant for his project, titled “The Role of the IL-1 Receptor in the AKI to CKD Transition.”

Multi-organ dysfunction syndrome (MODS) leads to significant morbidity and mortality in critically ill patients. Acute kidney injury (AKI) is one of the most common components of MODS. Unresolved AKI leads to ongoing renal injury, fibrosis, and subsequent chronic kidney disease (CKD). However, the mechanisms that direct kidney healing and prevent the AKI to CKD transition are poorly understood; and no treatment options exist to treat AKI or prevent CKD. One novel and promising therapeutic approach is to modulate the functions of immune cells that accumulate in the kidney to prevent further injury and fibrosis.

Privratsky’s overall hypothesis is that following AKI, activation of the receptor for the canonical pro-inflammatory cytokine interleukin-1 (IL-1R1) in macrophages and dendritic cells triggers renal cell injury and immune cell migration, which directs the adaptive immune system to propogate chronic kidney injury and fibrosis. Studies in this application will employ cell-specific deletion of IL-1R1 in macrophages and dendritic cells to study its effects on ischemic and septic kidney injury. He will use a combination of fluorescent cell sorting, single cell RNAseq, in vitro cell culture, and novel tissue cytometry methods to study immune cell-immune cell and immune cell-renal cell interactions in the context of kidney injury.

Privratsky hopes the findings of this project can facilitate the development of future novel immunomodulatory therapeutics to combat the significant burden of AKI.

“I take care of patients with AKI every day I am in the ICU, and I have no treatment options at my disposal,” says Privratsky, assistant professor of anesthesiology. “Over the course of my research career, my goal is to develop therapeutics to treat AKI and multi-organ failure. I am grateful for this K08 award as it will be vital as I establish myself as an independent investigator in critical care anesthesiology.”

Stacey HiltonDr. Privratsky Receives Clinical Investigator Award