VIPER: Chronic Pain after Amputation: Inflammatory Mechanisms, Novel Analgesic Pathways, and Improved Patient Safety.
Congressionally Directed Medical Research Program
This project is designed to determine whether two novel putative analgesic pathways discovered using Human VIPER amputee exome sequencing and metabolomic data may be therapeutic targets using animal models of neuropathic pain, astrocyte culture and validation of the initial pathway discovery in a separate human amputee cohort. In addition, this study will investigate genetic markers of opioid related adverse events. The Uniformed Services University of the Health Sciences and Vanderbilt University Medical Center are additional study sites.
Regional Anesthesia and Valproate Sodium for the Prevention of Chronic Post-Amputation Pain
Congressionally Directed Medical Research Program Log # PT1100575.
In this research we are testing the efficacy of valproic acid and regional anesthesia in the prevention of chronic post-amputation pain. We are additionally elucidating the underlying epigenetic mechanisms involved in the transition of acute to chronic pain and the effect of therapies on DNA methylation patterns.
Reconsidering Addiction and Opioid Abuse: Is there a causal chain between opioid addiction, morbidity, and mortality?
Duke Institute for Brain Sciences Bass Connections Award, 2016-2017
Perioperative Dexamethasone to Promote Systemic Pro-Resolution Phenotype for Prevention of Acute and Chronic Pain Post-Total Knee Arthroplasty.
This project studies the perioperative use of multiple dexamethasone dosing regimens before and after TKA, along with blood sample collection at multiple timepoints for macrophage phenotype analysis and plasma cytokine arrays.
Analysis of Gut Microbiota in Chronic Pain Patients.
This study involves microbiome analysis of patients with chronic overlapping pain conditions. It is being performed in collaboration with the company uBiome.
Effect of Thoracic Epidurals on the Incidence and Severity of Post-Thoracotomy Pain.
This study acts as a pilot project in anticipation of a larger therapeutic trial using DHA/EPA and their pro-resolution mediator metabolites to prevent chronic post-thoracotomy pain.