Overview

We are pleased to announce the inaugural Vascular and Neuroimmune Contributions to Brain Function Symposium. This event will focus on the evidence for the growing role of vascular and neuroimmune interactions during aging and neurodegeneration, including how these mechanisms lead to cognitive disorders and affect perioperative recovery. The symposium provides a natural forum to present new results, brainstorm, and discuss perspectives from a panel of experts in the field across multiple disciplines such as anesthesiology, neurobiology, bioengineering, and neuroimmunology. The panel discussion aims at highlighting opportunities across disciplines, including investigators from basic science and clinical research, to build community and advance team science to overcome challenges related to brain health and aging. 
 
We look forward to your active participation in making this program a success. 
 
We are grateful to the “Duke Faculty Advancement Seed Grant Program” for supporting this event.

Agenda

Time Lecture/Speaker
12:50−1:00 pm Welcoming Remarks
Joseph P. Mathew, MD, MBA, MHSc & Niccolò Terrando, BSc, DIC, PhD
1:00−2:00 pm KEYNOTE LECTURE: Neurovascular Determinants of Cognitive Health: From Vascular Cognitive Impairment to Neurodegeneration
Costantino Iadecola, MD
2:00−3:30 pm SESSION I

Modulation of Brain Myelination by the Meningeal Lymphatic System
Sandro Da Mesquita, PhD

Neuroimmune Cellular Communication: Downloading Data from the Dura Mater
Anthony Filiano, PhD 

Blood-Brain Barrier Changes in Postoperative Neurocognitive Disorders
Ting Yang, MD, PhD
3:30−3:45 pm COFFEE BREAK
3:45−5:15 pm SESSION II

Altered Neutrophil Reactivity Contributes to Microvascular Inflammation in an AD Mouse Model
Oliver Bracko, PhD

Bioelectronic Regulation of Neuroinflammation in Delirium Superposed on Dementia
Chengcheng Song, MD, PhD

Deciphering Neurovascular Inflammation Dynamics: An Engineering Approach with the Human-Derived Neurovascular Unit-on-a-Chip
Wonjae Lee, PhD
5:15−5:45 pm PANEL DISCUSSION AND COMMUNITY EVENT
Moderators:
Raphael H. Valdivia, PhD, Miriam Treggiari, MD, PhD
Panelists: Saskia Hemmers, PhD, Ashley Moseman, PhD, Mari Shinohara, PhD, Daniel Saban, PhD (and speakers)

Speakers

Meet the Keynote Speaker

Costantino Iadecola, MD

Director and Chair of the Feil Family Brain and Mind Research Institute
Anne Parrish Titzell Professor of Neurology
Weill Cornell Medicine, NY

Costantino Iadecola, MD

Costantino Iadecola, MD, is the director and chair of the Feil Family Brain and Mind Research Institute and the Anne Parrish Titzell Professor of Neurology at Weill Cornell Medicine. His research focuses on the basic mechanisms of neurovascular function and on the cellular and molecular alterations underlying ischemic brain injury, neurodegeneration, and other conditions associated with cognitive impairment.

A pioneer in establishing the concept of neurovascular unit, Dr. Iadecola has championed the involvement of neurovascular dysfunction in neurodegenerative diseases, and the role of innate immunity and the microbiome in ischemic brain injury. He has published more than 390 papers in peer-reviewed journals and plays a leadership role in research organizations and funding agencies in the United States and abroad. He has been involved as an editor or editorial board member in several journals, including Circulation Research, Stroke, Hypertension, the Journal of Neuroscience, and the Annals of Neurology. Dr. Iadecola has received the McHenry Award from the American Academy of Neurology, two Jacob Javits Awards from the National Institutes of Health, the Willis Award (the highest honor in stroke research bestowed by the American Heart Association (AHA)), the Zenith Fellow Award from the Alzheimer’s Association, the Excellence Award in Hypertension Research (Novartis) from the Hypertension Council of the AHA, and the Chancellor’s Award in Neuroscience from Louisiana State University. In 2015, he was elected to the Association of American Physicians. In 2019, Dr. Iadecola was selected as a Distinguished Scientist by the AHA, and in 2021, he received the Basic Science Prize from the AHA. Clarivate Analytics lists Dr. Iadecola as one of the world’s “Highly Cited Researchers” for ranking in the top one percent of the most-cited authors in the field of neuroscience and behavioral sciences.

Sandro Da Mesquita, PhD

Sandro Da Mesquita, PhD
Assistant Professor
Department of Neuroscience
Mayo Clinic
Jacksonville, FL

Anthony Filiano, PhD

Anthony Filiano, PhD
Assistant Professor
Department of Neurosurgery
Duke University
Durham, NC

Ting Yang, MD, PhD

Ting Yang, MD, PhD
Assistant Professor
Department of Medicine
Duke University
Durham, NC

Oliver Bracko, PhD

Oliver Bracko, PhD
Research Assistant Professor
Department of Biology
University of Miami, FL

Chengcheng Song, MD, PhD

Chengcheng Song, MD, PhD
Postdoctoral Fellow
Department of Anesthesiology
Duke University, Durham, NC

Wonjae Lee, PhD

Wonjae Lee, PhD
Assistant Professor
Department of Neurosurgery
Duke University, Durham, NC