Duke Anesthesiology Residency Program Ranked Among Top Five in the Nation

Duke Anesthesiology Residency Program Ranked Among Top Five in the Nation

On July 29, Doximity released its 2020-2021 Residency Navigator, once again ranking the Duke Anesthesiology Residency Program among the top five residency programs (by reputation) in its specialty, nationwide.

Doximity not only ranked the Duke Anesthesiology Residency Program #5 in the nation this year, it ranked the program #1 in the region (south) and #1 in the state of North Carolina.

Each year, Doximity and U.S. News & World Report collaborate to collect residency program reputation rankings, nationwide. This year’s Residency Navigator includes 4,700 residency programs across 28 specialties. These rankings are compiled from physician feedback from Doximity’s Residency Nomination Survey and the Residency Satisfaction Survey, along with objective data from a variety of public sources.

Stacey HiltonDuke Anesthesiology Residency Program Ranked Among Top Five in the Nation
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Dr. Ji Receives Prestigious Award

Ru-Rong Ji, PhD

We are pleased to announce that Dr. Ru-Rong Ji, distinguished professor of anesthesiology, has been selected to receive the prestigious 2020 American Society of Anesthesiologists (ASA) Excellence in Research Award. It recognizes individuals for outstanding achievement in research who has or is likely to have an important impact on the practice of anesthesiology. The individual’s work represents a body of original, mature and sustained contribution to the advancement of the science of anesthesiology. This is only one of two awards presented each year by the ASA to recognize the research accomplishments of members of our specialty.

“Several current and previous members of this department have received this award, and I am very proud to be one of them,” says Ji, chief of basic pain research and co-director of the department’s Center for Translational Pain Medicine (CTPM). “I really appreciate the full support I have received from the department over the last eight years.”

Ji’s work has significant translational potential in almost all areas of pain medicine. He currently serves as the director of the Sensory Plasticity and Pain Research Laboratory. Ji’s research focuses on molecular and cellular mechanisms of chronic pain, including but not limited to mediators of inflammation and pain, neuropathic pain, and cancer pain. He is internationally-recognized for his contributions to demonstrating critical roles of MAP kinase signaling pathways, glial cells, and neuroinflammation in the pathogenesis of chronic pain. His work has demonstrated powerful antinociceptive actions of pro-resolution lipid mediators (e.g., resolvins). His lab has shown that resolvins are among the most potent inhibitors for inflammatory pain and TRP channels. He also determined the down-stream GPCR signaling in macrophages and sensory neurons that mediates the potent actions of these lipid mediators. Recently, Ji’s work has focused on unique neuronal signaling of pattern recognition receptors, such as toll-like receptors (TLRs) and their contribution to pain and itch. And, Ji is notably among the first to establish a connection between mediators of cancer and pain processing showing that tumor cells produce PD-L1 to suppress not only the immune system, but also pain perception permitting cancer growth and metastasis. Ji also has established a broad collaboration with CTPM and Duke University School of Medicine faculty members to develop novel pain therapeutics.

“Dr. Ji is an outstanding scientist and colleague. He has a keen wit and is able to move scientific thought to the next level. Furthermore, he has the ability to implement his thoughts and ideas into productive, high-impact research. He clearly merits this award,” says Dr. William Maixner, vice chair for research and co-director of the CTPM.

Ji lectures internationally and reviews papers for numerous international journals. His research has been published in more than 200 peer reviewed manuscripts in high-impact journals, such as Science and Nature. Ji is one of 54 Duke researchers who made the global list of ‘Highly Cited Researchers’ for 2019; a list he also made in 2018. Ji also serves on editorial boards of Anesthesiology, Pain, Journal of Neuroscience, Neuroscience, and Neuroscience Bulletin. He previously served as an associate professor at Brigham and Women’s Hospital, Harvard Medical School, before joining the Duke faculty in 2012. He earned a PhD in neurobiology at Shanghai Institute of Physiology and completed postdoctoral training at Peking (Beijing) University Medical School, Karolinska Institute, and Johns Hopkins University School of Medicine.

Please join us in congratulating Ji on receiving this well-deserved award.

Stacey HiltonDr. Ji Receives Prestigious Award
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Postdoctoral Fellow Wins Highly-Competitive Awards

Christopher Donnelly, DDS, PhD

The American Association for Dental Research (AADR) and the International Association for Dental Research (IADR) has awarded Christopher Donnelly, DDS, PhD, postdoctoral fellow with Duke Anesthesiology, first place in both the AADR Hatton Awards competition (Postdoctoral category) and the IADR Unilever Hatton Awards competition (Senior – Basic Science category) for his project, titled “STING Agonism as a Therapeutic Strategy to Treat Chronic Pain.”

Donnelly competed against 26 finalists in the AADR Hatton Awards competition. As winner of that competition, he was selected to compete among 48 individuals from 24 IADR divisions and four sections selected in the IADR Unilever Hatton Awards competition.

In Donnelly’s project, they identified a new role for a protein, called STING, in the regulation of pain. STING is a well-known activator of the innate immune system, facilitating the elimination of infectious agents (bacteria, viruses) and potentially cancerous host cells. For this reason, STING has emerged as a promising target for cancer immunotherapy. In his study, they found that activation of STING in sensory neurons can provide robust and long-lasting pain relief in several chronic pain conditions, including cancer pain. Donnelly is hopeful that they can translate these encouraging results into human patients suffering from chronic pain, with a particular emphasis on patients suffering from severe and debilitating cancer pain. STING-based “neuroimmune” therapies could even provide a “two birds, one stone” approach to treating both the cancer itself and cancer-associated pain.

“I’m really fortunate to have been selected for both of these awards. At my career stage, this is considered one of the top honors a trainee can win in the field of dental and craniofacial research,” says Donnelly, a member of Dr. Ru-Rong Ji’s Sensory Plasticity and Pain Research Laboratory. He went on to say, “This project has been a huge undertaking by myself and many others. I’m happy to be recognized, but to me it’s more important to emphasize the contribution of my incredible mentors and collaborators, including Drs. Ji and William Maixner (Duke Anesthesiology), our collaborator at Wake Forest University, Dr. Mei-Chuan Ko, and my mentor at University of Michigan, Dr. Yu Lei, who helped inspire the project. I also want to recognize members of the Ji and Ko labs who have contributed significantly to this research, including Changyu Jiang, Kaiyuan Wang, Amanda Andriessen, Zilong Wang, Michael Lee, and Huiping Ding.” Donnelly is in his second year of postdoctoral studies at Duke, working under the supervision of Ji and Maixner.

“To me, winning this award affirms the translational potential of this project, the hard work and ingenuity of this amazing team of mentors and investigators, and underlines the impact of being in an outstanding research environment and a department invested in basic science research. I had high hopes in coming to Duke and it has exceeded all of my expectations. I look forward to seeing what we can continue to accomplish in the coming years,” adds Donnelly.

Stacey HiltonPostdoctoral Fellow Wins Highly-Competitive Awards
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Duke Anesthesiology Awarded Program Project Grant

Duke Anesthesiology Awarded Program Project Grant

The National Institutes of Health (NIH) has awarded Duke Anesthesiology a five-year, $8,566,593 million Center of Excellence award that is supported via the NIH’s Program Project Grant (PPG) mechanism. This is of substantial significance to the department and university because it marks the funding of a new national center and represents the first PPG to the department in 40 years.

The designation as a Center of Excellence within Duke Anesthesiology’s Center for Translational Pain Medicine (CTPM) by the National Center for Complementary and Integrative Health (NCCIH) brings this department both national and international recognition; there are only 1-3 Centers of Excellence funded as PPGs by NCCIH in the country. The new center represents a new and unique resource to investigators world-wide who have interest in translational pain research; it represents a nidus that not only advances Duke Anesthesiology’s mission in translational pain research, but brings it increased visibility in the pain field, which will further expand international collaboration and increase its value and recognition as a leader in translational pain medicine.

William Maixner, DDS, PhDWe want to sincerely thank everyone who helped drive the Center of Excellence initiative that has resulted in this extraordinary outcome. This award and designation is the culmination of a nearly three-year effort by the CTPM, initiated by the center’s co-directors, including Dr. William Maixner, who worked closely to develop the proposal with the center’s members and affiliates (*see complete list of names below).

The title of the PPG is “Resolution of Neuroinflammation and Persistent Pain by Complementary Approaches.” The overarching aims of the PPG is to identify new and novel complimentary approaches to the treatment of pain conditions. The PPG will support the intellectual development of the Center of Excellence and the infrastructure for three scientific projects and three support cores. These units will further bring together Duke Anesthesiology’s basic science and clinical groups to advance translational pain research.

*P01 collaborators: William Maixner, Shad Smith, Andrey Bortsov, Andrea Nackley, Sven-Eric Jordt, Niccolo Terrando, Luis Ulloa (Anesthesiology), Wolfgang Liedtke and Yong Chen (Anesthesiology and Neurology), Fan Wang (Neurobiology), and Staci Bilbo (Psychology and Neuroscience)

Stacey HiltonDuke Anesthesiology Awarded Program Project Grant
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Postdoctoral Associate Awarded Prestigious Grant

Ravikanth Velagapudi, PhDThe Network for Investigation of Delirium Unifying Scientists (NIDUS) has awarded Duke Anesthesiology’s Ravikanth Velagapudi, PhD, a 2019-2020 NIDUS Junior Investigator Pilot Award (12-month, $80,500 grant) for his proposal titled, “Profiling Postoperative Neuroinflammation in a Mouse Model of Delirium Superimposed on Parkinson’s Disease.”

Velagapudi’s proposal was selected through a rigorous review process from a pool of highly-competitive applications. His project will help gain fundamental knowledge on the impact of surgery on preclinical Parkinson’s disease (PD) models. Currently, millions of Americans live with PD and routinely undergo common surgical procedures, such as orthopedic surgery. Although lifesaving, surgery can increase the risk for cognitive complications like delirium, which in many cases associate with worse prognosis, increased health care costs, and even death. This is especially concerning in frail subjects and older adults who already suffer from ongoing neurodegeneration, such as Alzheimer’s disease, but also PD. This specific project will explore the effects of surgery-induced postoperative neuroinflammation in a genetic PD mouse model. Results from these experiments will provide novel understanding on how surgical trauma synergizes with PD pathology and may lead to novel therapeutic targets to treat delirium in subjects with ongoing PD pathology.

“It is a great opportunity to receive this pilot award from NIDUS under the junior investigator track to study delirium in PD,” says Velagapudi. “To date, this is a largely understudied subject, especially in the context of preclinical models and signaling mechanisms. In fact, few studies so far have addressed the effects of delirium on PD.” This pilot grant also provides a unique and timely opportunity to build a future career development research program for Velagapudi focusing on the interactions between postoperative delirium and PD-neurodegeneration.

Velagapudi is a postdoctoral associate in the Neuroinflammation and Cognitive Outcomes Laboratory in Duke Anesthesiology, led by Dr. Niccolò Terrando, who says this prestigious award is a remarkable accomplishment for his mentee. “I am very proud of Ravi’s achievement in just one year with my team. This award will provide an exceptional training opportunity and will further grow our collaboration with Dr. Laurie Sanders’ group in Duke Neurology, who are experts in PD pathogenesis.”

Velagapudi will present the findings of his project at the annual American Delirium Society meeting in 2021.

Stacey HiltonPostdoctoral Associate Awarded Prestigious Grant
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Dr. Wischmeyer Earns Education Award

Paul E. Wischmeyer, MD, EDICThe American Society of Parenteral and Enteral Nutrition (ASPEN) has selected Duke Anesthesiology’s Paul Wischmeyer, MD, EDIC, as the 2020 recipient of the Excellence in Nutrition Support Education Award. He was selected by national/international nominations by his peers and colleagues for this award, which recognizes a clinical nutrition educator’s excellence in the delivery of professional education.

According to Wischmeyer, this is among the highest awards for the education of dietitians, pharmacists, physicians, and other practitioners that ASPEN bestows.

“I am extremely honored to be nominated and chosen for this award by my peers in the nutrition field recognizing my contributions to nutrition education. Without doubt, teaching and lecturing on nutrition is one of my greatest career and life passions,” says Wischmeyer, professor of anesthesiology and associate vice chair for clinical research within Duke Anesthesiology. He also serves as the director of the TPN/Nutrition Support Team at Duke University Hospital.

“Clinical nutrition interventions, and the dietitians and others who provided it, have played an essential role in saving my life many times over during my ongoing hospitalizations and surgeries from Inflammatory Bowel Disease. Thus, my entire career has been committed to giving back to those who have given me so much to me, by focusing on the education of dietitians, pharmacists, physicians and patients on the critical role nutrition plays in patient outcomes and how to provide the best evidenced-based care for those we care for.”

Wischmeyer received this award virtually on March 30 at the ASPEN 2020 Nutrition Science and Practice Conference.

Stacey HiltonDr. Wischmeyer Earns Education Award
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