Boyi Liu, PhD, Assistant Professor of Anesthesiology, has recently been awarded a one-year, $9,200 voucher for his proposal entitled, “Transcriptome Profiling of Poison Ivy-Induced Allergic Contact Dermatitis by Microarray.”
The 2015 Spring Core Facility Voucher Program is a joint program with the School of Medicine (SOM), the Duke Translational Research Institute (DTRI) Pilot Program and the Office of the Provost. The program offers vouchers in amounts ranging from $500 to $10,000, redeemable for provision of services at School of Medicine core facilities/shared resources.
The School of Medicine departments, institutes and centers oversee a wide range of research core facilities. To enable investigators to access these services for exciting new studies that are not yet externally funded, they offer the 2015 Spring Core Facility Voucher Program to faculty at the assistant, associate, or professor level with primary appointments in the School of Medicine or Campus departments.
Allergic contact dermatitis (ACD) is a common skin condition triggered by environmental or occupational allergens. The most common ACD in the United States is caused by contact with poison ivy, with at least 10 million cases each year. However, surprisingly few studies have been published to explore the detailed mechanisms involved in poison ivy-induced ACD. The objective of this proposal is to perform a genome-wide transcriptome profiling of the skin from healthy, poison ivy and the well-established oxazolone ACD model by microarray in the two most popular mouse strains for ACD studies (C57BL/6 and BALB/c). The rationale is that this project will be important for the understanding of the mechanisms of the immune, inflammation and pruritus responses in poison ivy-induced ACD. Professor Liu’s long-term goal is to understand the mechanisms underlying the severe pruritus and inflammation in poison ivy ACD, and to develop mechanism-based treatments that will limit the use of high-dose steroids and provide a wider range of therapeutic options.