Research News

Winter 2014 DIG Report: Miklos Kertai, MD, PhD

Pharmacogenomics of β-blockers: Implication for Postoperative Atrial Fibrillation

The purpose of our study is to identify genetic variations in human genes that are responsible for modulating the efficacy of beta-blockers for the prevention of postoperative atrial fibrillation after heart surgery. For the purposes of the present study, we are using isolated DNA and human heart tissue from patients who underwent coronary artery bypass grafting (CABG) surgery at Duke University Medical Center.

Winter 2014 DIG Report: Michael Manning, MD, PhD

Cardiopulmonary Bypass-Induced Inflammatory Changes in the Atrial Wall: The Novel Role for Cardiac Chymase produced Angiotensin II in the Development of Atrial Fibrillation

Atrial fibrillation is a common complication following cardiac surgery because of the use of the heart-lung machine. Previously, it has been very difficult to make advances in treating this complication because of our inability to reproduce atrial fibrillation in animals, thereby hindering our ability to study what factors are the root causes of its development.

Winter 2014 DIG Report: Steve Melton, MD

Neurointerventional Regional Anesthesia to Improve Hand Rehabilitation in Stroke

Collaboration between investigators from anesthesiology, physical therapy, neurology, and the Brain Imaging and Analysis Center continues as planned.  Having completed manuscripts related to our preliminary fMRI investigation in healthy, human subjects, our current focus is on translating data from this work to the current project in stroke-affected individuals.

Winter 2014 DIG Report: Karthik Raghunathan, MD, MPH

Comparative effectiveness in Perioperative and Critical Care Medicine: Crystalloid Fluid Therapy

Different types of  Intravenous Fluids are widely used for the treatment of patients with serious infections who are admitted to the ICU. The conventional comparison has always been between fluids called, “crystalloids,” versus, “colloids.” Despite years of debate, these types of fluids have proved equivalent.

Winter 2012 DIG Report: Jorn A. Karhausen, MD

Determinants of Intestinal Epithelial Wound Healing

The main hypothesis of our proposal was that the local interplay of hypoxic and inflammatory mechanisms in intestinal ischemia/reperfusion injury plays an important role in epithelial recovery through the action of the transcription factor ZEB-1.

Spring 2013 DIG Report: Steve Melton, MD

Neurointerventional Regional Anesthesia to Improve Hand Rehabilitation in Stroke

This collaborative research project between investigators from anesthesiology, physical therapy, and neurology is proceeding as planned. Initial groundwork, preparation, and coordination have occurred to facilitate successful recruitment, enrollment and implementation of the study design and data collection. Additionally, the group is in the process of preparing multiple manuscripts related to our preliminary fMRI investigation in healthy, human subjects.

Winter 2012 DIG Report: Huaxin Sheng, MD

Effect of an Mn-porphyrin in Neuropathic Pain

With the support of our DIG, we developed two mouse models of spinal cord injury (SCI)-induced neuropathic pain in the lab.

Spring 2013 DIG Report: Karthik Raghunathan, MD, MPH

Comparative effectiveness in Perioperative and Critical Care Medicine: Crystalloid Fluid Therapy

Balanced salt solutions are often used for the treatment of dehydration among patients undergoing surgical procedures, while intravenous saline solutions are the most commonly used fluid among patients with serious infections.

Winter 2012 DIG Report: Mihai V. Podgoreanu, MD

Elucidating Adaptive Mechanisms of Perioperative Cardioprotection Following Ischemia-reperfusion in Hibernating Arctic Ground Squirrels

The overall goal of this study was to understand how hibernating animals have developed natural defense mechanisms to withstand extremes of environment, and to ultimately apply this knowledge for organ protection in humans undergoing heart surgery.

Spring 2013 DIG Report: Miklos Kertai, MD, PhD

Pharmacogenomics of β-blockers: Implication for Postoperative Atrial Fibrillation

The purpose of our study is to identify genetic variations in human genes that are responsible for modulating the efficacy of beta-blockers for the prevention of postoperative atrial fibrillation. For the purposes of the present study, we are using isolated DNA and human atrial tissue from patients who underwent coronary artery bypass grafting (CABG) surgery at Duke University Medical Center.